Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA, 19129, United States.
Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA, 19129, United States.
Neurosci Lett. 2021 May 14;753:135867. doi: 10.1016/j.neulet.2021.135867. Epub 2021 Apr 1.
Microtubule sliding is an underappreciated mechanism that contributes to the establishment, organization, preservation, and plasticity of neuronal microtubule arrays. Powered by molecular motor proteins and regulated in part by static crosslinker proteins, microtubule sliding is the movement of microtubules relative to other microtubules or to non-microtubule structures such as the actin cytoskeleton. In addition to other important functions, microtubule sliding significantly contributes to the establishment and maintenance of microtubule polarity patterns in different regions of the neuron. The purpose of this article is to review the state of knowledge on microtubule sliding in the neuron, with emphasis on its mechanistic underpinnings as well as its functional significance.
微管滑动是一种被低估的机制，它有助于神经元微管阵列的建立、组织、保存和可塑性。微管滑动是指微管相对于其他微管或非微管结构（如肌动蛋白细胞骨架）的运动，由分子马达蛋白驱动，并部分受静态交联蛋白调节。除了其他重要功能外，微管滑动还显著促进了神经元不同区域微管极性模式的建立和维持。本文的目的是综述神经元中微管滑动的研究现状，重点介绍其机械基础及其功能意义。
