Wang Jiangtao, Chen Shouhang, Wang Xiaoling, Gu Huiru, Liu Junli, Wang Xiaohong, Liu Liang
Department of Infant Ward, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, NO.33 Longhu East Road, Zhengzhou East District, Zhengzhou 450000, P.R. China.
Open Life Sci. 2019 Jul 22;14:358-362. doi: 10.1515/biol-2019-0040. eCollection 2019 Jan.
The cerebrospinal fluid content was examined for concentrations of S100 protein and neuron-specific enolase (NSE) in two diseases, Kawasaki disease (KD) with aseptic meningitis (1-3 months) and purulent meningitis (PM), to determine whether or not these measuremets could be used in early diagnosis. The content of cerebrospinal fluid S100 protein of KD with aseptic meningitis and PM were significantly higher than those in the control group. There was also a difference between KD and purulent meningitis (PM). The concentration of NSE was highest in the encephalitis group, which was statistically different from control group. However, there was no difference between the KD and control groups. The levels of S100 protein and NSE of KD with aseptic meningitis were lower than those in PM, indicating that the extent of neuronal damage is significantly lower than of the enchephalitis group. The area under the curve (AUCs) of the receiver operating characteristic (ROC) curve for S100 and NSE were both 0.972. The S100 threshold was 0.4315, the sensitivity was 92.1%, and the specificity was 100%, while the NSE threshold was 9.325, sensitivity 92.1%, and specificity 90%. The combined detection of NSE and S100 levels in the cerebrospinal fluid can be used for the differential diagnosis of KD with aseptic meningitis and purulent meningitis.
检测了两种疾病（1 - 3个月的川崎病（KD）合并无菌性脑膜炎和化脓性脑膜炎（PM））脑脊液中S100蛋白和神经元特异性烯醇化酶（NSE）的浓度，以确定这些检测指标是否可用于早期诊断。KD合并无菌性脑膜炎和PM患者脑脊液中S100蛋白含量显著高于对照组。KD和化脓性脑膜炎（PM）之间也存在差异。NSE浓度在脑炎组最高，与对照组有统计学差异。然而，KD组和对照组之间没有差异。KD合并无菌性脑膜炎患者的S100蛋白和NSE水平低于PM患者，表明神经元损伤程度明显低于脑炎组。S100和NSE的受试者工作特征（ROC）曲线下面积（AUCs）均为0.972。S100阈值为0.4315，灵敏度为92.1%，特异性为100%，而NSE阈值为9.325，灵敏度为92.1%，特异性为90%。脑脊液中NSE和S100水平的联合检测可用于KD合并无菌性脑膜炎和化脓性脑膜炎的鉴别诊断。
