Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.
Faculty of Social Sciences, Arts and Humanities, Kaunas University of Technology, Kaunas, Lithuania.
Cytokine. 2021 Jul;143:155510. doi: 10.1016/j.cyto.2021.155510. Epub 2021 Apr 3.
A poor outcome of whole-body hypothermia often results from a late complication, rather than from acute effects of hypothermia. A low body (cell) temperature or the increase in the concentrations of the stress hormones cortisol, epinephrine, and norepinephrine in response to acute cold stress have been proposed as potent proinflammatory cytokine suppressant. In the current study, we tested the hypothesis that the recovery of body temperature from a whole-body intermittent cold-water immersion (CWI, at 13-14 °C for a total 170 min) is associated with a delayed response of proinflammatory cytokines in young healthy men. Our results revealed a delay in the increase in the proinflammatory interleukin 6 and interleukin 1β cytokines after the CWI, which paralleled the changes in cortisol, epinephrine, norepinephrine, and body temperature. CWI decreased tumor necrosis factor α (TNF-α) immediately and 1 h after the CWI. Although TNF-α had recovered to the pre-immersion level at 2 h after CWI, its natural circadian cycle kinetics was disrupted until 12 h after the CWI. Furthermore, we showed that CWI strongly modified the white blood cell counts, with changes reaching a peak between 1 and 2 h after the CWI.
全身低温治疗的不良预后通常是由晚期并发症引起的，而不是由低温的急性影响引起的。有人提出，较低的体温（细胞）或对急性冷应激的应激激素皮质醇、肾上腺素和去甲肾上腺素浓度的增加，作为强力的促炎细胞因子抑制剂。在本研究中，我们检验了这样一个假设，即全身间歇性冷水浸泡（CWI，温度为 13-14°C，总时长 170 分钟）后体温的恢复与年轻健康男性促炎细胞因子的延迟反应有关。我们的结果显示，在 CWI 后，促炎细胞因子白细胞介素 6 和白细胞介素 1β 的增加出现延迟，这与皮质醇、肾上腺素、去甲肾上腺素和体温的变化相一致。CWI 立即降低了肿瘤坏死因子 α（TNF-α），并在 CWI 后 1 小时降低。尽管 TNF-α在 CWI 后 2 小时已恢复到浸泡前水平，但直到 CWI 后 12 小时，其自然昼夜节律动力学才被打乱。此外，我们表明，CWI 强烈地改变了白细胞计数，变化在 CWI 后 1 至 2 小时达到峰值。
