He Jian, Yang Xufang, Wang Hui
State Key Laboratory of Oncogenes and Related Genes Center for Single-Cell Omics School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China.
Department of Pathophysiology Mudanjiang Medical University Mudanjiang Heilongjiang China.
MedComm (2020). 2021 Mar;2(1):69-81. doi: 10.1002/mco2.53. Epub 2021 Jan 21.
COVID-19 is leading to a global pandemic and invades human cells via . was found to be abundantly expressed in many organs and cells. However, there is no evidence about the potential risk of various types of cancer patients vulnerable to the infection of COVID-19. To obtain a risk map that indicates the novel coronavirus vulnerability of different types of cancer, we analyzed in this work the RNA sequencing datasets of cancer patients. By interrogating the datasets, we not only identified the cancer types vulnerable to COVID-19 attacks, but also we reported that variations in the mRNA expression level of correlate to various prognosis phenomenon in different types of cancer cohorts, and illustrated the underlying mechanism involved or may be related to lymphocytes infiltration. From these discoveries, we constructed an infection risk map, which indicates the vulnerability of different types of cancer to COVID-19 infection, also elucidated the correlationship between and the prognosis of cancer. We found that high expression levels lead to high risk of COVID-19 infection and poor prognosis of breast invasive carcinoma (BRCA), while better prognosis in ovarian serous cystadenocarcinoma (OV) patient cohorts. Moreover, our study demonstrated that this different pattern may correlate with the immune infiltration level.
2019冠状病毒病正在引发全球大流行，并通过……侵入人体细胞。……被发现在许多器官和细胞中大量表达。然而，没有证据表明各类癌症患者易感染2019冠状病毒病存在潜在风险。为了获得一张显示不同类型癌症对新型冠状病毒易感性的风险图，我们在这项工作中分析了癌症患者的RNA测序数据集。通过审视这些数据集，我们不仅确定了易受2019冠状病毒病攻击的癌症类型，还报告了……的mRNA表达水平变化与不同类型癌症队列中的各种预后现象相关，并阐明了所涉及的潜在机制或可能与淋巴细胞浸润有关。基于这些发现，我们构建了一张感染风险图，该图显示了不同类型癌症对2019冠状病毒病感染的易感性，还阐明了……与癌症预后之间的相关性。我们发现，……高表达水平导致2019冠状病毒病感染风险高以及乳腺浸润性癌（BRCA）预后不良，而在卵巢浆液性囊腺癌（OV）患者队列中预后较好。此外，我们的研究表明，这种不同模式可能与免疫浸润水平相关。
