He Jian, Lin Yingxin, Meng Mei, Li Jingquan, Yang Jean Yh, Wang Hui
1State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
2School of Mathematics and Statistics, Charles Pekins Center, The University of Sydney, Sydney, Australia.
Aging Dis. 2021 Jun 1;12(3):705-709. doi: 10.14336/AD.2021.0301. eCollection 2021 Jun.
COVID-19 is now causing a global pandemic, there is a demand to explain the different clinical patterns between children and adults. To clarify the organs/cell types vulnerable to COVID-19 infection and the potential age-depended expression patterns of five factors (, , , , ) associated with clinical symptoms. In this study, we analyzed expression levels of five COVID-19 host dependency factors in multiple adult and fetal human organs. The results allowed us to grade organs at risk and also pointed towards the target cell types in each organ mentioned above. Based on these results we constructed an organ- and cell type-specific vulnerability map of the expression levels of the five COVID-19 factors in the human body, providing insight into the mechanisms behind the symptoms, including the non-respiratory symptoms of COVID-19 infection and injury. Also, the different expression patterns of the COVID-19 factors well demonstrate an explanation that the different clinical patterns between adult and children/infants.
新冠病毒病（COVID-19）目前正在引发全球大流行，因此需要解释儿童和成人之间不同的临床模式。以阐明易受COVID-19感染的器官/细胞类型以及与临床症状相关的五个因子（，，，，）潜在的年龄依赖性表达模式。在本研究中，我们分析了多种成人和胎儿人体器官中五个COVID-19宿主依赖性因子的表达水平。这些结果使我们能够对有风险的器官进行分级，并且还指出了上述每个器官中的靶细胞类型。基于这些结果，我们构建了人体中五个COVID-19因子表达水平的器官和细胞类型特异性易感性图谱，深入了解了症状背后的机制，包括COVID-19感染和损伤的非呼吸道症状。此外，COVID-19因子的不同表达模式很好地解释了成人与儿童/婴儿之间不同的临床模式。
