Medizinisches Versorgungszentrum Tempelhof Oncology, Berlin, Germany.
Department of Geriatrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Reinickendorfer Str. 61, 13347, Berlin, Germany.
J Cancer Res Clin Oncol. 2021 Jul;147(7):1917-1925. doi: 10.1007/s00432-021-03594-7. Epub 2021 Apr 6.
Patients with cancer often believe dietary supplements (DS) such as micronutrients and botanical products to be health supporting and non-toxic despite growing concerns regarding potential pharmacological interactions. Studies on the prevalence of DS use among patients with cancer are heterogeneous and mainly conducted at university-based cancer centers. This survey focused on a particular cancer patient group treated in an ambulatory setting without regular access to professional nutritional counselling.
Patients with a history of cancer or hematological malignancy were included in this survey. A self-reported questionnaire was used to evaluate the different aspects of DS use, changes in dietary habits and patients' demographic characteristics.
Almost every second patient reported using DS (47.2%). Women (56.3%), patients with an academic degree (56.0%) and non-smokers (84.8%) were more inclined to use DS. Along with magnesium (16.6%), calcium (14.3%), multivitamins (12.0%) and vitamin C (9.4%), use of herbal supplements (12.6%) was common. Women (84.8% vs. 74.9% of men, p = < 0.001) and patients younger than 65 years (84.4% vs. 77.2% of patients > 65 y, p = 0.002) sought dietary advice more often. Support of the immune system was the main reason for DS use (26.4%) and a relevant number of patients (49.6%) reported to have changed their dietary habits following cancer diagnosis.
DS use is common among patients with cancer treated in an ambulatory setting. This finding should encourage oncologists to implement detailed questioning about DS use and dietary habits to prevent potential interactions and offer substantial advice.
尽管人们对潜在的药物相互作用越来越关注，但癌症患者常认为膳食补充剂（DS），如微量营养素和植物产品，对健康有支持作用且无毒。关于癌症患者 DS 使用的患病率研究具有异质性，主要在大学癌症中心进行。本调查侧重于在门诊环境中接受治疗且无法定期获得专业营养咨询的特定癌症患者群体。
本研究纳入了有癌症或血液系统恶性肿瘤病史的患者。使用自我报告问卷评估 DS 使用的不同方面、饮食习惯的变化以及患者的人口统计学特征。
近一半的患者（47.2%）报告使用 DS。女性（56.3%）、具有学术背景的患者（56.0%）和不吸烟者（84.8%）更倾向于使用 DS。除了镁（16.6%）、钙（14.3%）、多种维生素（12.0%）和维生素 C（9.4%），草药补充剂（12.6%）的使用也很常见。女性（84.8%比男性 74.9%，p<0.001）和年龄小于 65 岁的患者（84.4%比年龄大于 65 岁的患者 77.2%，p=0.002）更常寻求饮食建议。支持免疫系统是使用 DS 的主要原因（26.4%），相当数量的患者（49.6%）在诊断出癌症后改变了饮食习惯。
在门诊环境中接受治疗的癌症患者中 DS 使用较为常见。这一发现应鼓励肿瘤学家详细询问 DS 使用和饮食习惯，以预防潜在的相互作用并提供实质性建议。
