Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2021 Apr 1;62(4):10. doi: 10.1167/iovs.62.4.10.
To investigate the change of border tissue configuration during axial elongation in childhood.
Fifty-four subjects (108 eyes; age range, 29.3-132.5 months) who had undergone a series of swept-source optical coherence tomography scans at intervals of 6 months or longer were classified into stable axial length (AXL) eyes (n = 55; AXL change of ≤0.36 mm) and elongating AXL eyes (n = 53; AXL change of >0.36 mm). The angle between the Bruch's membrane opening (BMO) reference plane and the border tissue of Elschnig was defined as the border tissue angle (BTA). The border tissue angle, BMO distance (BMOD) and minimum rim width (MRW) were measured in the temporal and nasal regions.
During 15.6 ± 7.2 months of follow-up, the AXL significantly increased from 22.8 ± 1.3 mm to 23.3 ± 1.4 mm (P < 0.001). Changes of border tissue angle and AXL showed a significant correlation only in the temporal region of elongating AXL eyes (r = -0.409; P = 0.002), but not in stable AXL eyes. Both BMOD and nasal MRW significantly increased from 1482.5 ± 153.0 to 1506.1 ± 154.6 µm and from 310.6 ± 83.2 to 324.6 ± 95.6 µm, respectively (all Ps < 0.001). The changes of BMOD and nasal MRW showed a significant positive correlation with changes of AXL in elongating AXL eyes but not in stable AXL eyes.
During the axial elongation in childhood, temporal border tissue configuration change, BMO enlargement, and nasal peripapillary tissue elevation showed a significant correlation with changes in the AXL.
研究儿童眼球轴长增加过程中边缘组织形态的变化。
对 54 例（108 只眼；年龄 29.3-132.5 个月）患者进行了一系列间隔 6 个月或更长时间的扫频源光学相干断层扫描，根据眼轴长度变化将其分为稳定眼轴长度（AXL）组（n=55；AXL 变化≤0.36mm）和伸长 AXL 组（n=53；AXL 变化＞0.36mm）。将 Bruch 膜开口（BMO）参考平面与 Elschnig 边缘组织之间的夹角定义为边缘组织角度（BTA）。测量颞侧和鼻侧的边缘组织角度、BMO 距离（BMOD）和最小 rim 宽度（MRW）。
在 15.6±7.2 个月的随访期间，AXL 从 22.8±1.3mm 显著增加到 23.3±1.4mm（P＜0.001）。伸长 AXL 眼中，AXL 变化与边缘组织角度变化仅在颞侧有显著相关性（r=-0.409，P=0.002），而在稳定 AXL 眼中则无。BMOD 和鼻侧 MRW 分别从 1482.5±153.0µm 显著增加到 1506.1±154.6µm 和从 310.6±83.2µm 显著增加到 324.6±95.6µm（均 P＜0.001）。伸长 AXL 眼中，BMOD 和鼻侧 MRW 的变化与 AXL 的变化呈显著正相关，但在稳定 AXL 眼中则无。
在儿童眼球轴长增加过程中，颞侧边缘组织形态变化、BMO 扩大和鼻侧视盘周围组织隆起与 AXL 的变化有显著相关性。
