Samsung Medical Center, Department of Ophthalmology, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Department of Ophthalmology, Dongguk University Gyeongju Hospital, Dongguk University School of Medicine, Gyeongju-si, Gyeongsangbuk-do, Republic of Korea.
Sci Rep. 2021 Apr 8;11(1):7726. doi: 10.1038/s41598-021-87336-2.
This retrospective comparative study was to evaluate tear osmolarity measured by I-Pen osmolarity system (I-MED Pharma Inc, Dollard-des-Ormeaux, Quebec, Canada) in healthy subjects without dry eye disease (DED) and patients with DED, and its association with other ocular surface parameters. This study comprised 65 eyes of 65 patients. The ocular surface parameters including tear osmolarity with I-Pen osmometer of the patients who visited the refractive surgery center of Samsung Medical Center between January 1, 2020 and May 31, 2020 were retrospectively collected. The subjects were divided as asymptomatic normal group and symptomatic dry eye group. The distribution of tear osmolarity and its association with other ocular surface parameters were evaluated. Total thirty-two patients (32 eyes) were included in the control group, and 33 patients (33 eyes) were included in the DED group. Tear osmolarity was significantly higher in the DED group. Tear osmolarity was negatively correlated with tear break-up time, and the Schirmer test, and was positively correlated with Ocular Surface Disease Index symptom score. The cut-off value of 318 mOsm/L showed a sensitivity of 90.9% and specificity of 90.6% for diagnosing DED. The I-Pen osmometer can be considered suitable for use in the clinical setting, with good performance in DED diagnosis.
这项回顾性对比研究旨在评估使用 I-Pen 渗透压系统（I-MED Pharma Inc，加拿大魁北克多尔德-德斯-奥梅尔）测量健康受试者（无干燥性眼疾病（DED））和 DED 患者的泪液渗透压，并研究其与其他眼表参数的相关性。本研究纳入了 2020 年 1 月 1 日至 2020 年 5 月 31 日期间在三星医疗中心屈光手术中心就诊的 65 例 65 只眼患者的眼表参数，包括使用 I-Pen 渗透压仪测量的泪液渗透压。根据是否有眼干症状，将患者分为无症状正常组和有症状干眼组，评估泪液渗透压的分布及其与其他眼表参数的相关性。对照组纳入 32 例（32 只眼），DED 组纳入 33 例（33 只眼）。DED 组的泪液渗透压显著升高。泪液渗透压与泪膜破裂时间和 Schirmer 试验呈负相关，与眼表疾病指数（OSDI）症状评分呈正相关。318 mOsm/L 作为诊断 DED 的截断值，其诊断的灵敏度为 90.9%，特异度为 90.6%。I-Pen 渗透压仪可用于临床，在 DED 诊断方面具有良好的性能。
