Arabi Monfared Ali, Ayatollahi Mousavi Seyyed Amin, Zomorodian Kamiar, Mehrabani Davood, Iraji Aida, Moein Mahmood Reza
Department of Medical Mycology and Parasitology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Curr Med Mycol. 2020 Sep;6(3):1-8. doi: 10.18502/cmm.6.3.3979.
Aromatic waters (AWs) are therapeutic distillates, which harbor both essential oil and water-soluble components of a plant. Due to the dispersion of the light amount of essence through the AWs, they have their specific pleasant smell, taste, and medicinal properties. In Iranian traditional medicine, AW is used to treat gastrointestinal disorders. The present study was conducted to determine the chemical composition of the essential oil extracted from AW and its antifungal activities against species.
The composition of the essential oil extracted from AW was analyzed by gas chromatography-mass spectrometry. In addition, the evaluation of the antifungal activity of AW against species was performed using broth microdilution methods as recommended by the Clinical Laboratory Standard Institute. Moreover, the biofilm formation inhibition, antioxidant properties, and experimental activity of AW were determined in an animal model.
According to the results, thymol (78.08%) was the major compound of EO, followed by carvacrol (8.20%) and carvotanacetone (6.50%). Furthermore, AW exhibited antifungal activities against the examined fungi and inhibited the biofilm formation of C. albicans at a concentration of up to 0.25 V/V. Histopathological analyses revealed that colonization declined in the mice following the administration of AW in a therapeutic trial.
It seems that the presence of phenolic monoterpenes in AW has resulted in antifungal effects. Pleasant odor and antioxidant properties are extra bonuses to the antimicrobial effects of this plant. Based on the findings, AW might have the potential to be used in the management of alimentary candidiasis or oral hygienic products.
芳香水是具有治疗作用的蒸馏液,含有植物的精油和水溶性成分。由于少量精油分散在芳香水中,它们具有独特的宜人气味、味道和药用特性。在伊朗传统医学中,芳香水用于治疗胃肠道疾病。本研究旨在确定从芳香水中提取的精油的化学成分及其对某些菌种的抗真菌活性。
采用气相色谱-质谱联用仪分析从芳香水中提取的精油的成分。此外,按照临床实验室标准协会的建议,采用肉汤微量稀释法评估芳香水对某些菌种的抗真菌活性。此外,还在动物模型中测定了芳香水的生物膜形成抑制、抗氧化特性和实验活性。
结果显示,百里香酚(78.08%)是精油的主要成分,其次是香芹酚(8.20%)和香芹酮(6.50%)。此外,芳香水对所检测的真菌表现出抗真菌活性,并在浓度高达0.25 V/V时抑制白色念珠菌的生物膜形成。组织病理学分析显示,在一项治疗试验中,给小鼠施用芳香水后,其体内的(真菌)定植有所减少。
芳香水中酚类单萜的存在似乎导致了抗真菌作用。宜人的气味和抗氧化特性是这种植物抗菌作用的额外优势。基于这些发现,芳香水可能有潜力用于治疗消化道念珠菌病或口腔卫生产品中。