Beghi Ettore, Michael Benedict D, Solomon Tom, Westenberg Erica, Winkler Andrea S
Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Ann Neurol. 2021 Apr 9;89(6):1059-67. doi: 10.1002/ana.26076.
There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of SARS-CoV2 infection and neurological complications, with standardised forms for pooled data analyses that non-specialists can use, including in low-income settings. This article is protected by copyright. All rights reserved.
关于新冠病毒病（COVID-19）神经学表现的研究数量正在不断增加。然而，研究设计不一致、对照不充分、测试验证不佳以及不同的环境、干预措施和文化规范削弱了研究质量、可比性，进而影响了对这些并发症的范围、负担和病理生理学的理解。因此，一个全球COVID-19神经研究联盟与世界卫生组织（WHO）一起，审查了COVID-19神经并发症的报告，并统一了未来研究的临床措施。这将有助于开展设计良好的研究，使用精确、一致的严重急性呼吸综合征冠状病毒2（SARS-CoV2）感染和神经并发症病例定义，以及供非专业人员使用的标准化汇总数据分析表格，包括在低收入环境中。本文受版权保护。保留所有权利。
