mRNA 在神经胶质中的运输和局部翻译。
mRNA Transport and Local Translation in Glia.
机构信息
Department of Biology, Stanford University, Stanford, CA, USA.
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Trends Cell Biol. 2021 Jun;31(6):419-423. doi: 10.1016/j.tcb.2021.03.006. Epub 2021 Apr 8.
Abstract
Though mRNA transport and local translation are extensively studied in neurons, emerging evidence supports that these cellular processes are also abundant in non-neuronal glial cells. Here, we explore mechanisms of mRNA transport and local translation in oligodendrocytes, astrocytes, microglia, radial glia, and their functions in development, structure, and intercellular interactions.
摘要
尽管在神经元中广泛研究了 mRNA 的运输和局部翻译，但新出现的证据支持这些细胞过程在非神经元神经胶质细胞中也很丰富。在这里，我们探讨了少突胶质细胞、星形胶质细胞、小胶质细胞、放射状胶质细胞中 mRNA 运输和局部翻译的机制，以及它们在发育、结构和细胞间相互作用中的功能。
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