长链非编码RNA LINC00152与KLF5的正反馈环促进乳腺癌生长。
A Positive Feedback Loop of Long Noncoding RNA LINC00152 and KLF5 Facilitates Breast Cancer Growth.
作者信息
Li Qiang, Wang Xiao, Zhou Liheng, Jiang Mingyun, Zhong Guansheng, Xu Shuguang, Zhang Minjun, Zhang Yigan, Liang Xiaodong, Zhang Lei, Tang Jianming, Zhang Haibo
机构信息
Department of Radiation Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Department of Medical Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
出版信息
Front Oncol. 2021 Mar 26;11:619915. doi: 10.3389/fonc.2021.619915. eCollection 2021.
The long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor survival prognosis. Further studies revealed that LINC00152 knockdown suppresses cell proliferation and tumorigenicity and . Mechanistic analyses demonstrated that LINC00152 directly binds to KLF5 protein and increases KLF5 stability. Moreover, LINC00152 is also a KLF5-responsive lncRNA, and KLF5 activates LINC00152 transcription by directly binding to its promoter. Our study suggests that LINC00152 promotes tumor progression by interacting with KLF5. LINC00152 may be a valuable prognostic predictor for breast cancer, and the positive feedback loop of LINC00152-KLF5 could be a therapeutic target in pharmacological strategies.
长链非编码RNA（lncRNA）LINC00152，也称为CYTOR，在多种癌症中呈现异常表达。然而，其在乳腺癌中的临床价值和功能机制仍未得到充分了解。我们的研究发现，LINC00152在乳腺癌中显著上调，并且它是生存预后不良的一个指标。进一步研究表明，敲低LINC00152可抑制细胞增殖和肿瘤发生。机制分析证明，LINC00152直接与KLF5蛋白结合并增加KLF5的稳定性。此外，LINC00152也是一种KLF5反应性lncRNA，并且KLF5通过直接结合其启动子来激活LINC00152转录。我们的研究表明，LINC00152通过与KLF5相互作用促进肿瘤进展。LINC00152可能是乳腺癌一个有价值的预后预测指标，并且LINC00152-KLF5的正反馈环可能是药物策略中的一个治疗靶点。
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