School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China.
J Asian Nat Prod Res. 2022 Feb;24(2):163-169. doi: 10.1080/10286020.2021.1912027. Epub 2021 Apr 12.
A new amide, named rehmagluamide (), and a new hydroxycinnamic acid derivative, named nepetoidin F (), together with six known compounds, 2'--methyluridine (), puroglutamic acid (), biliverdic acid (), peterolactam (), nicotinic acid (), nicotinamide (), were isolated from the fresh roots of . All the structures of compounds were identified by the interpretation of their spectroscopic data and comparison with those reported in the literatures. The protective effects of compounds on normal rat kidney tubule epithelioid (NRK-52e) cells injury induced by LPS were investigated. The results indicated that compounds , , and exhibited protective effects against LPS-induced NRK 52e cells injury.
从新鲜的当归根部分离得到一个新的酰胺，命名为 rehmagluamide ()，和一个新的羟基肉桂酸衍生物，命名为 nepetoidin F ()，以及另外六个已知化合物，2'--甲基尿苷 ()、吡咯谷氨酸 ()、胆红素酸 ()、彼得洛拉坦 ()、烟酸 ()、烟酰胺 ()。所有化合物的结构都是通过对其光谱数据的解释以及与文献报道的比较来确定的。研究了化合物对脂多糖诱导的正常大鼠肾近曲小管上皮细胞（NRK-52e）损伤的保护作用。结果表明，化合物 、 和 对 LPS 诱导的 NRK52e 细胞损伤具有保护作用。
