Lagerkvist B E, Linderholm H, Nordberg G F
Department of Environmental Medicine, University of Umeå, Sweden.
Int Arch Occup Environ Health. 1988;60(5):361-4. doi: 10.1007/BF00405671.
Occupational and environmental exposure to inorganic arsenic is associated with the occurrence of Raynaud's phenomenon and objectively registered abnormal finger systolic blood pressure at local cooling (FSP). A subnormal FSP during cooling indicates a vasospastic tendency. It is not known whether these phenomena are related to recent or historical long-term exposure to arsenic. Twenty-one workers from a Swedish smelter were selected on the basis of exposure to arsenic dust for more than 14 years and a previously (three years earlier) recorded subnormal FSP during local cooling. The workers were examined before and after a 4 to 8 week summer vacation. After this intermission in arsenic exposure the urinary excretion of arsenic decreased to normal values, whereas the vasospastic reaction in the fingers remained. Thus the vasospastic tendency seems to be unrelated to the most recent urinary arsenic levels. FSP levels on cooling were significantly increased as compared with the measurements made three years earlier. This suggests a gradual improvement in finger blood circulation caused by decreased exposure to arsenic as evaluated over a time period of several years. The data thus indicate that peripheral vascular disturbances caused by arsenic are dependent on long-term arsenic exposures and are independent of short-term fluctuations in arsenic exposure.
职业性和环境性接触无机砷与雷诺现象的发生以及局部冷却时客观记录的手指收缩压异常（FSP）有关。冷却过程中FSP低于正常水平表明存在血管痉挛倾向。目前尚不清楚这些现象是否与近期或既往长期砷暴露有关。从瑞典一家冶炼厂挑选了21名工人，这些工人接触砷尘超过14年，且之前（三年前）记录到局部冷却时FSP低于正常水平。在为期4至8周的暑假前后对这些工人进行了检查。在砷暴露中断后，尿砷排泄降至正常水平，而手指的血管痉挛反应依然存在。因此，血管痉挛倾向似乎与最近的尿砷水平无关。与三年前的测量结果相比，冷却时的FSP水平显著升高。这表明，在数年的时间段内评估，由于砷暴露减少，手指血液循环逐渐改善。因此，数据表明，砷引起的外周血管紊乱取决于长期砷暴露，与砷暴露的短期波动无关。
