Dela Justina Vanessa, Giachini Fernanda R, Priviero Fernanda, Webb R Clinton
Graduate Program in Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Graduate Program in Biological Sciences, Federal University of Goiás, Goiânia, Brazil; Institute of Health Sciences and Health, Universidad Federal De Mato Grosso, Barra Do Garcas, Brazil.
Vascul Pharmacol. 2021 Oct;140:106861. doi: 10.1016/j.vph.2021.106861. Epub 2021 Apr 22.
The virus responsible for the coronavirus disease of 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest that COVID-19 could trigger cardiovascular complications in apparently healthy patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a pathogen-associated molecular pattern (PAMP)/ danger-associated molecular patterns (DAMP). Interestingly, Toll-like receptor (TLR) 3 recognize both PAMPs DAMPs and is activated by viral double-stranded RNA (dsRNA) leading to activation of TIR receptor domain-containing adaptor inducing IFN-β (TRIF) dependent pathway. New evidence has shown a link between virus dsRNA and increased BP. Hence, we hypothesize that COVID-19 infection may be over activating the TLR3 through dsRNA, evoking further damage to the patients, leading to vascular inflammation and increased blood pressure, favoring the development of several cardiovascular complications, including hypertension.
导致2019冠状病毒病（COVID-19）的病毒是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。有证据表明，COVID-19可能会在看似健康的患者中引发心血管并发症。冠状病毒是包膜正链RNA病毒，作为病原体相关分子模式（PAMP）/危险相关分子模式（DAMP）。有趣的是，Toll样受体（TLR）3既能识别PAMP和DAMP，又能被病毒双链RNA（dsRNA）激活，从而导致含TIR受体结构域的接头诱导IFN-β（TRIF）依赖性途径的激活。新证据表明病毒dsRNA与血压升高之间存在联系。因此，我们推测COVID-19感染可能通过dsRNA过度激活TLR3，对患者造成进一步损害，导致血管炎症和血压升高，有利于包括高血压在内的几种心血管并发症的发展。
