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一项系统评价与荟萃分析：免疫抑制的皮肤鳞状细胞癌患者中β-人乳头瘤病毒的评估

A Systematic Review and Meta-Analysis: Evaluation of the β-Human Papillomavirus in Immunosuppressed Individuals with Cutaneous Squamous Cell Carcinoma.

作者信息

Ramezani Mazaher, Baharzadeh Farideh, Almasi Afshin, Sadeghi Masoud

机构信息

Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Biomedicine (Taipei). 2020 Dec 1;10(4):1-10. doi: 10.37796/2211-8039.1110. eCollection 2020.

DOI:10.37796/2211-8039.1110
PMID:33854928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7735980/
Abstract

BACKGROUND

Some types of beta-human papillomavirus (β-HPV) may be one of the probable causes of squamous cell carcinoma (SCC) in transplant recipients. β-HPVs are linked to SCC in the literature with small number of subjects.

AIM

Herein, the first meta-analysis was carried out on the association between β-HPVs and cutaneous SCC in immunosuppressed patients.

METHODS

A systematic search was carried out in the PubMed and Scopus databases up to December 2018. The odds ratio (OR) were calculated by RevMan 5.3 software and the event rate (ER) by Comprehensive Meta-Analysis 2.0 software with a 95% confidence interval (CI).

RESULTS

A total of 1250 records were identified through the two databases, but at last eleven studies were included in the meta-analysis that they were published from 1989 to 2018. The results showed a significantly high prevalence of β-HPVs in cutaneous SCC patients (ER = 69.1%; 95%CI: 58.7%, 77.8%). In addition, the prevalence of overall β-HPVs and β-HPVs of 5, 8, 9, 17, 49, 75, and 76 in immunosuppressed cutaneous SCC patients was significantly higher compared with controls.

CONCLUSIONS

The findings of the present meta-analysis support the hypothesis that β-HPV may play a role in cutaneous SCC development in immunosuppressed individuals.

摘要

背景

某些类型的β-人乳头瘤病毒（β-HPV）可能是移植受者鳞状细胞癌（SCC）的可能病因之一。在文献中，β-HPV与SCC的关联研究对象数量较少。

目的

本文首次对免疫抑制患者中β-HPV与皮肤SCC之间的关联进行荟萃分析。

方法

截至2018年12月，在PubMed和Scopus数据库中进行了系统检索。采用RevMan 5.3软件计算比值比（OR），采用Comprehensive Meta-Analysis 2.0软件计算事件发生率（ER），并给出95%置信区间（CI）。

结果

通过这两个数据库共识别出1250条记录，但最终纳入荟萃分析的有11项研究，这些研究发表于1989年至2018年。结果显示，皮肤SCC患者中β-HPV的患病率显著较高（ER = 69.1%；95%CI：58.7%，77.8%）。此外，免疫抑制的皮肤SCC患者中总体β-HPV以及5、8、9、17、49、75和76型β-HPV的患病率与对照组相比显著更高。

结论

本荟萃分析的结果支持β-HPV可能在免疫抑制个体的皮肤SCC发生中起作用这一假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/43dda1d8c2e8/bmed-10-04-001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/09a76f9a8001/bmed-10-04-001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/476b81f18681/bmed-10-04-001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/5d0d8b9878d1/bmed-10-04-001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/94bdeaa21e67/bmed-10-04-001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/43dda1d8c2e8/bmed-10-04-001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/09a76f9a8001/bmed-10-04-001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/476b81f18681/bmed-10-04-001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/5d0d8b9878d1/bmed-10-04-001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/94bdeaa21e67/bmed-10-04-001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9784/7735980/43dda1d8c2e8/bmed-10-04-001f5.jpg

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