Center for Micro-ElectroMechanical Systems (CMEMS-UMINHO), University of Minho, Guimarães, Portugal.
Clínica do Dragão, Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal.
Cartilage. 2021 Dec;13(2_suppl):1700S-1719S. doi: 10.1177/19476035211007902. Epub 2021 Apr 15.
To analyze the effects of light therapy (LT) on cartilage repair for knee osteoarthritis (OA) treatment.
The PubMed, Embase, Scopus, and Web of Science databases were searched up to August 31, 2020 to identify and studies that analyzed the effects of LT on knee cartilage for OA treatment. The study and sample characteristics, LT intervention parameters and posttreatment outcomes were analyzed. Risk of bias was assessed using the Risk of Bias Assessment for Non-randomized Studies (RoBANS) tool.
Three and 30 studies were included. Most studies were judged as high risk of performance and detection bias. Biochemical outcomes were analyzed for both i and studies, and histological and behavioral outcomes were analyzed for studies. LT reduced extracellular matrix (ECM) degradation, inflammation, and OA progression, promoting ECM synthesis. LT improved pain-like behavior in animal models, having no apparent effect on gait performance. There were conflicting findings of some of the biochemical, histological, and behavioral outcomes.
The included studies presented different strategies and LT parameters. LT resulted in positive effects on cartilage repair and may be an adequate therapy for OA treatment.
分析光疗（LT）对膝骨关节炎（OA）治疗中软骨修复的影响。
检索 PubMed、Embase、Scopus 和 Web of Science 数据库，截至 2020 年 8 月 31 日，以确定分析 LT 对 OA 治疗中膝关节软骨影响的 和 研究。分析研究和样本特征、LT 干预参数和治疗后结果。使用非随机研究偏倚风险评估工具（RoBANS）评估偏倚风险。
纳入 3 项 和 30 项 研究。大多数研究被认为具有较高的实施和检测偏倚风险。生物化学结果同时分析了 和 研究，组织学和行为学结果分析了 项 研究。LT 减少了细胞外基质（ECM）降解、炎症和 OA 进展，促进了 ECM 合成。LT 改善了动物模型的疼痛样行为，对步态表现没有明显影响。一些生物化学、组织学和行为学结果存在相互矛盾的发现。
纳入的研究提出了不同的策略和 LT 参数。LT 对软骨修复有积极影响，可能是 OA 治疗的一种合适的治疗方法。
