Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, The Netherlands.
Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, The Netherlands.
Biochem Pharmacol. 2021 Sep;191:114563. doi: 10.1016/j.bcp.2021.114563. Epub 2021 Apr 19.
Aging is a multifactorial process likely stemming from damage accumulation and/or a decline in maintenance and repair mechanisms in the organisms that eventually determine their lifespan. In our review, we focus on the morphological and functional alterations that the aging brain undergoes affecting sleep and the circadian clock in both human and rodent models. Although both species share mammalian features, differences have been identified on several experimental levels, which we outline in this review. Additionally, we delineate some challenges on the preferred analysis and we suggest that a uniform route is followed so that findings can be smoothly compared. We conclude by discussing potential interventions and highlight the influence of physical exercise as a beneficial lifestyle intervention, and its effect on healthy aging and longevity. We emphasize that even moderate age-matched exercise is able to ameliorate several aging characteristics as far as sleep and circadian rhythms are concerned, independent of the species studied.
衰老是一个多因素的过程，可能源于生物体损伤的积累和/或维持和修复机制的下降，而这些最终决定了它们的寿命。在我们的综述中，我们关注的是衰老大脑在形态和功能上的改变，这些改变会影响人类和啮齿动物模型中的睡眠和生物钟。尽管这两个物种都具有哺乳动物的特征，但在几个实验层面上已经发现了差异，我们在这篇综述中进行了概述。此外，我们还描述了一些在首选分析方面的挑战，并建议遵循统一的路线，以便能够顺利地比较研究结果。最后，我们讨论了潜在的干预措施，并强调了体育锻炼作为一种有益的生活方式干预的影响，以及它对健康衰老和长寿的影响。我们强调，即使是适度的与年龄匹配的运动也能够改善与睡眠和昼夜节律有关的几个衰老特征，而与所研究的物种无关。
