来自西沙软珊瑚长枝麒麟叶的新的半日花烷型倍半萜。

Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum.

机构信息

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; Biology Department, College of Life and Environment Science, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, People's Republic of China.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.

出版信息

Fitoterapia. 2021 Jun;151:104906. doi: 10.1016/j.fitote.2021.104906. Epub 2021 Apr 12.

DOI:10.1016/j.fitote.2021.104906

PMID:33857589

Abstract

Further chemical investigation of the Xisha soft coral Litophyton nigrum has resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely linardosinenes D-G (1-4). The structures of new compounds were elucidated by extensive analyses of their spectroscopic data and by comparison with the reported data of known related ones. All compounds exhibited weak inhibitory effect against bromodomain-containing protein 4 (BRD4), a promising therapeutic target in various human diseases, at a concentration of 10 μM.

摘要

进一步对西沙软珊瑚 Litophyton nigrum 的化学成分研究，从中分离得到四个新的角鲨烷型倍半萜，分别命名为 linardosinenes D-G（1-4）。通过对其光谱数据的综合分析和与文献报道的相关已知化合物数据的比较，确定了新化合物的结构。所有化合物在 10 μM 浓度下对溴结构域蛋白 4（BRD4）表现出较弱的抑制作用，BRD4 是多种人类疾病中很有前途的治疗靶点。