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利用模糊证据推理评估传染病爆发风险。

Assessing the Outbreak Risk of Epidemics Using Fuzzy Evidential Reasoning.

机构信息

School of Economics and Management, Beijing Jiaotong University, Beijing, China.

Chinese National Medical Products Administration, Beijing, China.

出版信息

Risk Anal. 2021 Nov;41(11):2046-2064. doi: 10.1111/risa.13730. Epub 2021 Apr 17.

Abstract

Epidemic diseases (EDs) present a significant but challenging risk endangering public health, evidenced by the outbreak of COVID-19. Compared to other risks affecting public health such as flooding, EDs attract little attention in terms of risk assessment in the current literature. It does not well respond to the high practical demand for advanced techniques capable of tackling ED risks. To bridge this gap, an adapted fuzzy evidence reasoning method is proposed to realize the quantitative analysis of ED outbreak risk assessment (EDRA) with high uncertainty in risk data. The novelty of this article lies in (1) taking the lead to establish the outbreak risk evaluation system of epidemics covering the whole epidemic developing process, (2) combining quantitative and qualitative analysis in the fields of epidemic risk evaluation, (3) collecting substantial first-hand data by reviewing transaction data and interviewing the frontier experts and policymakers from Chinese Centers for Disease Control and Chinese National Medical Products Administration. This work provides useful insights for the regulatory bodies to (1) understand the risk levels of different EDs in a quantitative manner and (2) the sensitivity of different EDs to the identified risk factors for their effective control. For instance, in the case study, we use real data to disclose that influenza has the highest breakout risk level in Beijing. The proposed method also provides a potential tool for evaluating the outbreak risk of COVID-19.

摘要

传染病(EDs)是对公共卫生构成重大但具有挑战性的风险,COVID-19 的爆发就是明证。与洪水等其他影响公共卫生的风险相比,传染病在当前文献的风险评估中并没有受到太多关注。它不能很好地应对处理传染病风险的先进技术的高实际需求。为了弥补这一差距,提出了一种改进的模糊证据推理方法,以实现对风险数据高度不确定的传染病爆发风险评估(EDRA)的定量分析。本文的新颖之处在于:(1)率先建立了涵盖整个传染病发展过程的传染病爆发风险评估体系;(2)在传染病风险评估领域进行了定量和定性分析的结合;(3)通过审查交易数据并采访中国疾病预防控制中心和中国国家药品监督管理局的前沿专家和政策制定者,收集了大量的第一手数据。这项工作为监管机构提供了有益的见解,使他们能够:(1)以定量的方式了解不同传染病的风险水平;(2)了解不同传染病对已确定风险因素的敏感性,从而对其进行有效控制。例如,在案例研究中,我们使用真实数据揭示了流感在北京的爆发风险水平最高。所提出的方法还为评估 COVID-19 的爆发风险提供了一种潜在的工具。

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