Department of Anesthesiology and Intensive Care Medicine, Park-Klinik Weissensee, Schönstrasse 80, 13086 Berlin, Germany.
Department of Anesthesiology, Intensive Care and Emergency Medicine, Pain Medicine, BG Klinikum Hamburg, Bergedorfer Strasse 10, 21033 Hamburg, Germany.
Alcohol. 2021 Aug;94:57-63. doi: 10.1016/j.alcohol.2021.04.001. Epub 2021 Apr 14.
To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.
This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Temperature data were obtained and matched with the associated rescue mission data, which were divided into the following groups: 1) alcohol poisoning, 2) opioid poisoning, 3) poisoning by sedatives/hypnotics, multiple drugs, volatile solvents, and other psychoactive substances. Lowess-Regression analysis was performed to assess the relationship between ambient temperature and frequency of severe acute poisoning. Additionally, three temperature ranges were defined in order to compare them with each other with regard to frequency of severe poisoning (<10 °C vs. 10-20 °C vs. >20 °C). The severity of emergencies was assessed using the National Advisory Committee for Aeronautics (NACA) scoring system.
In 1535 patients, severe acute alcohol or drug poisoning associated with loss of consciousness, hypotension, and impaired respiratory function was treated (alcohol: n = 604; opioids: n = 295; sedatives/hypnotics/multiple drugs: n = 636). Compared to mild temperatures (10-20 °C), the frequency of poisoning increased in all three groups at higher temperatures and decreased at lower temperatures (p < 0.01). No significant correlation was found between severity of emergencies and temperature.
Our results suggest a continuously increasing probability of occurrence of severe acute poisoning by alcohol and drugs with rising temperature.
验证在较高环境温度而非较低环境温度下，酒精和药物引发的严重急性中毒更频繁这一假说。
这是一项在海洋西海岸气候条件下的院前环境中进行的前瞻性观察性研究。对汉堡市（德国）急救医疗服务的数据和当地气象站的数据进行了为期 5 年的评估。获取了温度数据并将其与相关的救援任务数据进行匹配，这些数据分为以下几组：1）酒精中毒，2）阿片类药物中毒，3）镇静剂/催眠药、多种药物、挥发性溶剂和其他精神活性物质中毒。使用低通回归分析来评估环境温度与严重急性中毒频率之间的关系。此外，还定义了三个温度范围，以便彼此比较严重中毒的频率（<10°C 与 10-20°C 与 >20°C）。使用国家航空咨询委员会（NACA）评分系统评估紧急情况的严重程度。
在 1535 名因意识丧失、低血压和呼吸功能受损而接受严重急性酒精或药物中毒治疗的患者中（酒精：n=604；阿片类药物：n=295；镇静剂/催眠药/多种药物：n=636），与温和温度（10-20°C）相比，所有三组在较高温度下的中毒频率增加，在较低温度下的中毒频率降低（p<0.01）。紧急情况的严重程度与温度之间未发现显著相关性。
我们的研究结果表明，随着温度升高，酒精和药物引发的严重急性中毒的发生概率呈持续上升趋势。
