Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN.
Dermatol Online J. 2021 Mar 15;27(3):13030/qt5vp5f7bq.
Keratoacanthoma centrifugum marginatum (KCM) is an uncommon variant of keratoacanthoma. Keratoacanthoma centrifugum marginatums are most commonly seen on sun-exposed surfaces and present with progressive peripheral expansion and raised, hyperkeratotic borders. Central clearing with atrophy and lack of spontaneous clearance are other key clinical characteristics. The majority of cases are benign with a low risk of metastasis. The size of such growths is variable with reported cases ranging from 5.0cm×5.0cm to as large as 20.0cm×14.0cm. Treatment options include surgical excision, oral retinoids, and intralesional chemotherapeutics such as methotrexate or bleomycin. We herein present a case of KCM manifesting as an exophytic, crateriform plaque in a 61-year-old man.
离心性环状边缘性角层瘤（KCM）是角层瘤的一种罕见变异型。离心性环状边缘性角层瘤最常发生于暴露于阳光的表面，表现为进行性外周扩展和隆起的角化过度边界。中央萎缩和缺乏自发性消退是另一个关键的临床特征。大多数病例为良性，转移风险低。这种生长的大小是可变的，报道的病例范围从 5.0cm×5.0cm 到 20.0cm×14.0cm 不等。治疗选择包括手术切除、口服类维甲酸和局部化疗药物，如甲氨蝶呤或博来霉素。本文报告了一例表现为外生性、火山口样斑块的 KCM 病例，患者为 61 岁男性。
