补充谷氨酰胺对心血管代谢风险因素和炎症标志物的影响：系统评价和荟萃分析。
Effect of glutamine supplementation on cardiometabolic risk factors and inflammatory markers: a systematic review and meta-analysis.
机构信息
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran.
出版信息
BMC Cardiovasc Disord. 2021 Apr 17;21(1):190. doi: 10.1186/s12872-021-01986-8.
BACKGROUND
Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers.
METHODS
The processes of systematic reviews and meta-analyses were performed according to the PRISMA checklist. PubMed, Web of Sciences, Cochrane library, and Scopus databases were search for relevant studies without time or language restrictions up to December 30, 2020. All randomized clinical trials which assessed the effect of glutamine supplementation on "glycemic indices", "level of triglyceride, "and "inflammatory markers" were included in the study. The effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers was assessed using a standardized mean difference (SMD) and 95% confidence interval (CI). Heterogeneity between among studies was assessed using Cochran Q-statistic and I-square. Random/fixed-effects meta-analysis method was used to estimate the pooled SMD. The risk of bias for the included trials was evaluated using the Cochrane quality assessment tool.
RESULTS
In total, 12 studies that assessed the effect of glutamine supplementation on cardio-metabolic risk factors were included in the study. Meta-analysis showed that glutamine supplementation significantly decreased significantly serum levels of FPG [SMD: - 0.73, 95% CI - 1.35, - 0.11, I: 84.1%] and CRP [SMD: - 0.58, 95% CI - 0.1, - 0.17, I: 0%]. The effect of glutamine supplementation on other cardiometabolic risk factors was not statistically significant (P > 0.05).
CONCLUSION
Our findings showed that glutamine supplementation might have a positive effect on FPG and CRP; both of which are crucial as cardio-metabolic risk factors. However, supplementation had no significant effect on other cardio-metabolic risk factors.
背景
有证据表明，谷氨酰胺在葡萄糖代谢、胰岛素敏感性和抗炎作用中发挥多种作用。本系统评价和荟萃分析的对照试验旨在评估谷氨酰胺补充对心脏代谢危险因素和炎症标志物的影响。
方法
根据 PRISMA 清单进行系统评价和荟萃分析。在没有时间和语言限制的情况下，于 2020 年 12 月 30 日之前在 PubMed、Web of Sciences、Cochrane 图书馆和 Scopus 数据库中搜索相关研究。所有评估谷氨酰胺补充对“血糖指数”、“甘油三酯水平”和“炎症标志物”影响的随机临床试验均纳入研究。使用标准化均数差（SMD）和 95%置信区间（CI）评估谷氨酰胺补充对心脏代谢危险因素和炎症标志物的影响。使用 Cochran Q 统计量和 I 平方评估研究之间的异质性。使用随机/固定效应荟萃分析方法估计汇总 SMD。使用 Cochrane 质量评估工具评估纳入试验的偏倚风险。
结果
共有 12 项研究评估了谷氨酰胺补充对心脏代谢危险因素的影响，被纳入本研究。荟萃分析显示，谷氨酰胺补充显著降低了血清 FPG [SMD：-0.73，95%CI：-1.35，-0.11，I：84.1%]和 CRP [SMD：-0.58，95%CI：-0.1，-0.17，I：0%]水平。谷氨酰胺补充对其他心脏代谢危险因素的影响没有统计学意义（P>0.05）。
结论
我们的研究结果表明，谷氨酰胺补充可能对 FPG 和 CRP 有积极影响，这两者都是心脏代谢危险因素的关键指标。然而，补充剂对其他心脏代谢危险因素没有显著影响。
Zotero 插件