Tang Fei, Yan Hong-Ling, Wang Li-Xia, Xu Jin-Feng, Peng Cheng, Ao Hui, Tan Yu-Zhu
State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2021 Apr 1;12:627458. doi: 10.3389/fphar.2021.627458. eCollection 2021.
For decades, chronic diseases including cardiovascular and cerebrovascular diseases (CCVDs) have plagued the world. Meanwhile, we have noticed a close association between CCVDs and vascular lesions, such as hypertension. More focus has been placed on TMPs and natural products with vasodilation and hypotension. TMPs with vasodilatory and hypotensive activities are mainly from , , and (such as , , , , etc.) whereas natural products eliciting vasorelaxant potentials were primarily from flavonoids, phenolic acids and alkaloids (such as apigenin, puerarin, curcumin, sinomenine, etc.). Furthermore, the data analysis showed that the vasodilatory function of TMPs was mainly concerned with the activation of eNOS, while the natural products were primarily correlated with the blockage of calcium channel. Thus, TMPs will be used as alternative drugs and nutritional supplements, while natural products will be considered as potential therapies for CCVDs in the future. This study provides comprehensive and valuable references for the prevention and treatment of hypertension and CCVDs and sheds light on the further studies in this regard. However, since most studies are and preclinical, there is a need for more in-depth researches and clinical trials to understand the potential of these substances.
几十年来，包括心脑血管疾病（CCVDs）在内的慢性疾病一直困扰着全球。与此同时，我们注意到CCVDs与血管病变（如高血压）之间存在密切关联。人们更多地关注具有血管舒张和降血压作用的天然产物和传统中药。具有血管舒张和降血压活性的传统中药主要来源于[具体来源1]、[具体来源2]和[具体来源3]（如[列举具体药物1]、[列举具体药物2]、[列举具体药物3]、[列举具体药物4]等），而具有血管舒张潜力的天然产物主要来源于黄酮类、酚酸类和生物碱类（如芹菜素、葛根素、姜黄素、青藤碱等）。此外，数据分析表明，传统中药的血管舒张功能主要与内皮型一氧化氮合酶（eNOS）的激活有关，而天然产物主要与钙通道的阻断相关。因此，传统中药将用作替代药物和营养补充剂，而天然产物在未来将被视为CCVDs的潜在治疗方法。本研究为高血压和CCVDs的预防和治疗提供了全面且有价值的参考，并为这方面的进一步研究提供了思路。然而，由于大多数研究都是[此处原文缺失相关描述]且处于临床前阶段，因此需要进行更深入的研究和临床试验，以了解这些物质的潜力。
