Bawazeer Saud, Rauf Abdur
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, P.O. Box 42, Makkah 21955, Saudi Arabia.
Department of Chemistry University of Swabi, Swabi, Anbar 23430, KPK, Pakistan.
ACS Omega. 2021 Apr 1;6(14):9852-9856. doi: 10.1021/acsomega.1c00537. eCollection 2021 Apr 13.
Anti-inflammatory, analgesic, and sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, and other complications. In this regard, discovery research is undergoing a process to discover effective, safe, and economical drugs with no side effects. The aim of this study was to assess chloroform extracts and isolated compounds for anti-inflammatory, analgesic, and sedative activities in animal models. The anti-inflammatory potential was measured by using the carrageenan-induced and histamine-induced paw edema procedure, while the analgesic potential was determined using a hot plate analgesiometer. The sedative effect was observed in an animal model for screening of the locomotor effect of the extract and isolated compound . Our data exhibited that the extract and compound attenuated carrageenan-induced and histamine-induced paw edema (93.98 and 89.54%, respectively). Furthermore, compound attenuated biphasic edema associated with histamine and prostaglandins. The chloroform extract showed a moderate analgesic effect; however, compound showed a significant analgesic potential ( < 0.001) by increasing the latency time of the animals in the thermally induced algesia model. Compound exhibited a significant sedative effect and dose-dependent analgesic activity. It is concluded that the chloroform extract and compound showed remarkable anti-inflammatory, analgesic, and sedative activities. This research work strongly rationalizes the folkloric usage of in the treatment of inflammation, pain, and insomnia.
抗炎、镇痛和镇静药物在使用时会产生许多副作用，包括消化性溃疡、头痛、成瘾和其他并发症。在这方面，探索性研究正在进行，以发现有效、安全且经济且无副作用的药物。本研究的目的是评估氯仿提取物和分离出的化合物在动物模型中的抗炎、镇痛和镇静活性。通过角叉菜胶诱导和组胺诱导的爪肿胀程序来测定抗炎潜力，同时使用热板镇痛仪来确定镇痛潜力。在动物模型中观察镇静作用，以筛选提取物和分离出的化合物的运动效应。我们的数据显示，提取物和化合物分别减轻了角叉菜胶诱导和组胺诱导的爪肿胀（分别为93.98%和89.54%）。此外，化合物减轻了与组胺和前列腺素相关的双相水肿。氯仿提取物显示出中等程度的镇痛作用；然而，化合物通过增加热诱导痛觉过敏模型中动物的潜伏期，显示出显著的镇痛潜力（<0.001）。化合物表现出显著的镇静作用和剂量依赖性镇痛活性。得出的结论是，氯仿提取物和化合物表现出显著的抗炎、镇痛和镇静活性。这项研究工作有力地证明了民间使用[药物名称未给出]治疗炎症、疼痛和失眠的合理性。
