麻栎素 A-E，来自麻栎（Lour.）Corner 的抗菌类黄酮。
Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis (Lour.) Corner.
机构信息
Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
出版信息
Phytochemistry. 2021 Jul;187:112773. doi: 10.1016/j.phytochem.2021.112773. Epub 2021 Apr 16.
The phytochemical investigation of the fruit and leaf extracts of Maclura cochinchinensis (Lour.) Corner (Moraceae) resulted in the isolation and identification of four undescribed isoflavones (macluracochinones A-D) and one undescribed flavone (macluracochinone E), together with 24 known compounds. The structures of the undescribed compounds were elucidated using nuclear magnetic resonance (NMR) and high-resolution electrospray ionization time-of-flight mass spectrometry (HRESITOFMS) experiments. Gancaonin M, lupiwighteone, lupalbigenin, warangalone, auriculatin, and millexatin F displayed good antibacterial activities against Gram-positive bacteria with MIC values in the range of 1-8 μg/mL. Lupalbigenin showed strong activities against methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus with the same MIC value of 1 μg/mL.
对构树（桑科）果实和叶提取物的植物化学研究，分离并鉴定出四个新的异黄酮（构树异黄酮 A-D）和一个新的黄酮（构树异黄酮 E），以及 24 种已知化合物。利用核磁共振（NMR）和高分辨率电喷雾电离飞行时间质谱（HRESITOFMS）实验阐明了未知化合物的结构。Gancaonin M、lupiwighteone、lupalbigenin、warangalone、auriculatin 和 millexatin F 对革兰氏阳性菌具有良好的抗菌活性，MIC 值范围为 1-8μg/mL。Lupalbigenin 对耐甲氧西林金黄色葡萄球菌（MRSA）和金黄色葡萄球菌表现出很强的活性，MIC 值相同，均为 1μg/mL。
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