Jia C Y, Chen L X
Department of Burns and Plastic & Wound Repair Surgery, Xiang'an Hospital of Xiamen University, Xiamen 361102, China.
Zhonghua Shao Shang Za Zhi. 2021 Apr 20;37(4):301-305. doi: 10.3760/cma.j.cn501120-20200529-00289.
In clinical work, it is observed that keloid has significantly different characteristics from other types of scar such as hypertrophic scar. The growth of keloid usually exceeds the margin of original wound and continuously invades the surrounding skin, and keloid has a certain recurrence rate after various treatment measures such as surgery and glucocorticoid injection, etc. The above phenomenon suggests that keloid has certain tumor characteristics, and we cannot judge keloid from the perspective of scar alone. This article attempts to re-describe the pathogenesis of keloid from the perspective of tumor and summarizes the tumor characteristics of keloid from self-sufficiency of growth signal, avoidance of apoptosis, and abnormal angiogenesis, etc.
在临床工作中观察到,瘢痕疙瘩与其他类型的瘢痕如增生性瘢痕具有显著不同的特征。瘢痕疙瘩的生长通常超出原始伤口边缘并持续侵犯周围皮肤,并且在手术和糖皮质激素注射等各种治疗措施后,瘢痕疙瘩有一定的复发率。上述现象表明瘢痕疙瘩具有一定的肿瘤特征,我们不能仅从瘢痕的角度来判断瘢痕疙瘩。本文试图从肿瘤的角度重新描述瘢痕疙瘩的发病机制,并从生长信号的自给自足、逃避凋亡和异常血管生成等方面总结瘢痕疙瘩的肿瘤特征。