State Key Laboratory of Bioelectronics, School of Biological Science and Medical EngineeringSoutheast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.
Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, P. R. China.
Adv Mater. 2021 Jun;33(22):e2007356. doi: 10.1002/adma.202007356. Epub 2021 Apr 19.
Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal-polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.
多酚是一类含有酚羟基的有机分子，广泛存在于天然植物中，对人体健康具有有益的作用。最近，由于具有抗氧化、抗癌活性和普遍的黏附亲和力，含多酚的纳米粒子引起了广泛的研究关注，因此在多功能纳米组装体的制备、稳定和修饰方面具有很大的应用前景，例如生物成像、治疗药物输送和其他生物医学应用。此外，多酚和金属离子之间的配位相互作用形成的金属-多酚网络，已被用于制备一类重要的含多酚纳米粒子，用于表面修饰、生物成像、药物输送和疾病治疗。本文重点关注多酚与不同材料（例如金属离子、无机材料、聚合物、蛋白质和核酸）之间的相互作用，对含多酚纳米粒子的合成和性质进行了全面的综述。此外，还展示了含多酚纳米粒子在生物检测、多模式生物成像、蛋白质和基因输送、骨修复、抗菌和癌症治疗等不同生物医学应用中的显著多功能性。最后，讨论了含多酚纳米粒子未来研究面临的挑战。
