马缨丹毒素多晶型对豚鼠致黄疸作用的影响。
Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs.
作者信息
Sharma O P, Dawra R K, Makkar H P
机构信息
Biochemistry Laboratory, Indian Veterinary Research Institute, Kangra Valley.
出版信息
Toxicol Lett. 1988 Jul;42(1):29-37. doi: 10.1016/0378-4274(88)90099-9.
A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.
从马缨丹（马缨丹，红色品种）叶片中分离出的一种部分纯化的毒素制剂，称为C组分，有两种结晶形式：I型，白色、蓬松、棒状；II型，不规则、多面体、闪亮晶体。给豚鼠口服时，这两种形式在熔点行为和致黄疸作用方面有所不同。只有II型对豚鼠有致黄疸作用，并伴有采食量和粪便排出量减少、肝肿大、血浆胆红素水平升高以及酸性磷酸酶活性增加。
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