Lu Fang, Ma Yurong, Huang Hui, Zhang Yue, Kong Hui, Zhao Yan, Qu Huihua, Wang Qingguo, Liu Yang, Kang Zhenhui
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Nanoscale. 2021 Apr 14;13(14):6809-6818. doi: 10.1039/d1nr01099a. Epub 2021 Apr 7.
The incidence rate of stress ulcers has increased in recent years, with an increase in life pressure, unavoidable trauma and other factors. The therapy of acute stress ulcers has always been an important challenge. Carbon dots (CDs) have been reported to show excellent biological activities, but research on the stress ulcer curative effect of CDs is unprecedented. Here, we prepared a series of semi-carbonized nanodots (SCNDs) from natural plants or herbs as precursors and the as prepared SCNDs were later proved to be effective in the treatment and inhibition of stress gastric ulcers in a rat model. One kind of SCND from edible and medicinal plants, charred Atractylodes macrocephala (SCNDs-1), is demonstrated in detail for its strong anti-stress gastric ulcer effect with inhibition up to 90% and shows extremely high biocompatibility and ultra-low toxicity. These SCNDs lead to the reduction of inflammatory factors and oxidative stress, and the protection of the gastric mucosa. The SCNDs also reduce the excessive neuroendocrine response caused by stress, regulate the energy metabolism and the structure of intestinal flora, improve the damage to the body caused by the stress state, thus alleviating the occurrence of stress-induced gastric ulcers. This work provides new insights into the preparation of carbon nanomaterials from natural plants through a semi-carbonization process and opens new ways to apply bio-active and bio-safe SCNDs in the modern pharmaceutical field.
近年来，随着生活压力增加、不可避免的创伤等因素，应激性溃疡的发病率有所上升。急性应激性溃疡的治疗一直是一项重大挑战。据报道，碳点（CDs）具有出色的生物活性，但关于碳点对应激性溃疡治疗效果的研究尚无先例。在此，我们以天然植物或草药为前体，制备了一系列半碳化纳米点（SCNDs），随后证明所制备的SCNDs在大鼠模型中对应激性胃溃疡的治疗和抑制有效。详细展示了一种来自药食两用植物的SCND，即焦白术（SCNDs - 1），其具有很强的抗应激性胃溃疡作用，抑制率高达90%，且显示出极高的生物相容性和超低毒性。这些SCNDs可减少炎症因子和氧化应激，保护胃黏膜。SCNDs还可减轻应激引起的过度神经内分泌反应，调节能量代谢和肠道菌群结构，改善应激状态对机体造成的损害，从而缓解应激性胃溃疡的发生。这项工作为通过半碳化过程从天然植物制备碳纳米材料提供了新的见解，并为在现代制药领域应用具有生物活性和生物安全性的SCNDs开辟了新途径。
