AlAteeq Mohammed A, AlShail Abdulaziz, AlZahrani Amal, AlNafisah Osama, Masuadi Emad, Alshahrani Awad
Family Medicine, Ministry of National Guard - Health Affairs, King Abdullah International Medical Research Center (KAIMRC), Riyadh, SAU.
Research Unit/Biostatistics, King Saud Bin Abdulaziz University for Health Sciences/King Abdullah International Medical Research Center (KAIMRC), Riyadh, SAU.
Cureus. 2021 Mar 16;13(3):e13929. doi: 10.7759/cureus.13929.
Background Vitamin D deficiency is a prevalent condition worldwide. Identification of optimal supplementation approaches for maintaining normal vitamin D level in healthy adults is still required. It has been clearly established that sun exposure and diet do not provide the recommended daily amount of vitamin D, and that vitamin D supplementation is needed to maintain normal levels in the Saudi population. The aim of this study was to compare the efficacy of two regimens, monthly and bimonthly doses of 50,000 International Units (IU) cholecalciferol (vitamin D3), in maintaining normal serum levels of 25-hydroxyvitamin D in Saudi adults. Methods This study was a randomized controlled trial conducted to compare the efficacy of three regimens in maintaining a normal level of vitamin D in adult individuals. The study took place at three primary healthcare centers in King Abdul-Aziz Medical City, Riyadh, Saudi Arabia. A total of 65 participants were enrolled and randomly divided into two intervention groups and one control group. All participants were contacted by researchers and followed up at their corresponding primary health care center for two successive visits. Results All 65 participants completed the study. The participants were mostly females (49; 75.4%); the mean age was 42.1 years (±13.5). The difference in vitamin D levels after three months of the trial was statistically significant among the three groups. A decrease in vitamin D level was recorded in the control group and in the once monthly intake of 50,000 IU group. The bimonthly intake of 50,000 IU group maintained statistically significant vitamin D levels > 75. Conclusion Bimonthly vitamin D3 supplementation appears to be an efficient regimen for maintaining a normal level of 25(OH)D, regardless of the amount of vitamin D obtained from diet and sun exposure.
维生素D缺乏在全球范围内普遍存在。仍需要确定在健康成年人中维持正常维生素D水平的最佳补充方法。已经明确的是，阳光照射和饮食无法提供推荐的每日维生素D摄入量，沙特人群需要补充维生素D以维持正常水平。本研究的目的是比较两种方案，即每月和每两个月服用50,000国际单位（IU）胆钙化醇（维生素D3），在维持沙特成年人血清25-羟基维生素D正常水平方面的疗效。方法：本研究是一项随机对照试验，旨在比较三种方案在成年个体中维持正常维生素D水平的疗效。该研究在沙特阿拉伯利雅得阿卜杜勒-阿齐兹国王医疗城的三个初级医疗保健中心进行。共招募了65名参与者，并随机分为两个干预组和一个对照组。所有参与者均由研究人员联系，并在其相应的初级医疗保健中心进行连续两次随访。结果：所有65名参与者均完成了研究。参与者大多为女性（49名；75.4%）；平均年龄为42.1岁（±13.5）。试验三个月后，三组之间的维生素D水平差异具有统计学意义。对照组和每月服用一次50,000 IU组的维生素D水平有所下降。每两个月服用一次50,000 IU组维持的维生素D水平>75，具有统计学意义。结论：无论从饮食和阳光照射中获得的维生素D量如何，每两个月补充一次维生素D3似乎是维持25(OH)D正常水平的有效方案。
