Chin J Dent Res. 2021 Apr 23;24(1):9-20. doi: 10.3290/j.cjdr.b1105867.
To describe the current scientific knowledge concerning stem cells obtained from the pulp of discarded primary teeth and to discuss their contribution to dental tissue engineering, a narrative review of the relevant literature published in the past decade (2010-2019) in the PubMed database was conducted. The promise that stem cells from human exfoliated deciduous teeth (SHED) hold as a viable biological option to heal diseased dental organs has been the focus of research over the past decade. New ways of inducing higher levels of differentiation through various bioactive agents and scaffolds have been pursued. Attention has also been paid to the regeneration potential of the discarded pulp tissue that originates from high caries risk or inflamed teeth. In conclusion, the field of stem cell engineering is constantly evolving, and although there is still much to learn about the behaviour of SHED, there are endless opportunities for their exploitation in dental regeneration.
为了描述从废弃的乳牙牙髓中获得的干细胞的当前科学知识，并讨论它们对牙科组织工程的贡献，对过去十年（2010-2019 年）在 PubMed 数据库中发表的相关文献进行了叙述性综述。过去十年的研究重点一直是，人类脱落乳牙（SHED）中的干细胞作为一种可行的生物选择，有希望治愈患病的牙齿器官。人们一直在寻求通过各种生物活性物质和支架来诱导更高水平分化的新方法。人们还关注起源于高龋齿风险或发炎牙齿的废弃牙髓组织的再生潜力。总之，干细胞工程领域正在不断发展，尽管人们对 SHED 的行为还有很多需要了解的地方，但在牙齿再生方面，它们的应用潜力是无穷的。
