Ascher H, Holm K, Kristiansson B, Mäki M
Gothenburg University, Department of Paediatrics I, East Hospital, Göteborg, Sweden.
Arch Dis Child. 1993 Sep;69(3):375-80. doi: 10.1136/adc.69.3.375.
Against the background of reported different trends of incidence and presentation of coeliac disease in Sweden and Finland, a joint study was done to explore potential causes. The clinical study confirmed that classical symptoms and diagnosis before 2 years of age dominated in Sweden. In Finland, the symptoms were more diffuse and diagnosis in most cases was made after the age of 8 years. A significantly lower weight score attained at diagnosis was seen in Swedish patients compared with Finnish. No significant difference in HLA expression was found. Infant feeding was investigated by studying food records of healthy infants. Swedish infants ingested three times more wheat protein at 9 months and twice as much at 12 months compared with Finnish children. It is concluded that the intake of infant cereal protein might influence when and how clinical coeliac disease appears. The question whether or not it is important for if coeliac disease will be acquired still remains to be answered.
在瑞典和芬兰报道的乳糜泻发病率和临床表现存在不同趋势的背景下，开展了一项联合研究以探究潜在原因。临床研究证实，瑞典以2岁前出现的典型症状和诊断为主。在芬兰，症状更为分散，大多数病例在8岁以后才得以诊断。与芬兰患者相比，瑞典患者在诊断时的体重得分显著更低。未发现HLA表达存在显著差异。通过研究健康婴儿的食物记录来调查婴儿喂养情况。与芬兰儿童相比，瑞典婴儿在9个月时摄入的小麦蛋白是其3倍，在12个月时是其2倍。得出的结论是，婴儿谷物蛋白的摄入量可能会影响临床乳糜泻出现的时间和方式。乳糜泻是否会发病，摄入谷物蛋白是否重要，这个问题仍有待解答。
