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VRNetzer 平台支持在虚拟现实中进行交互式网络分析。

The VRNetzer platform enables interactive network analysis in Virtual Reality.

机构信息

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna, Austria.

出版信息

Nat Commun. 2021 Apr 23;12(1):2432. doi: 10.1038/s41467-021-22570-w.

Abstract

Networks provide a powerful representation of interacting components within complex systems, making them ideal for visually and analytically exploring big data. However, the size and complexity of many networks render static visualizations on typically-sized paper or screens impractical, resulting in proverbial 'hairballs'. Here, we introduce a Virtual Reality (VR) platform that overcomes these limitations by facilitating the thorough visual, and interactive, exploration of large networks. Our platform allows maximal customization and extendibility, through the import of custom code for data analysis, integration of external databases, and design of arbitrary user interface elements, among other features. As a proof of concept, we show how our platform can be used to interactively explore genome-scale molecular networks to identify genes associated with rare diseases and understand how they might contribute to disease development. Our platform represents a general purpose, VR-based data exploration platform for large and diverse data types by providing an interface that facilitates the interaction between human intuition and state-of-the-art analysis methods.

摘要

网络为复杂系统中的交互组件提供了强大的表示形式,使其成为可视化和分析大数据的理想选择。然而,许多网络的大小和复杂性使得在通常大小的纸张或屏幕上进行静态可视化变得不切实际,导致出现所谓的“一团糟”。在这里,我们引入了一个虚拟现实 (VR) 平台,通过促进对大型网络的全面可视化和交互式探索来克服这些限制。我们的平台通过允许导入自定义数据分析代码、集成外部数据库以及设计任意用户界面元素等功能,实现了最大程度的定制和可扩展性。作为概念验证,我们展示了如何使用我们的平台来交互式地探索基因组规模的分子网络,以识别与罕见疾病相关的基因,并了解它们如何促成疾病的发展。我们的平台通过提供一个界面,促进了人类直觉和最先进的分析方法之间的交互,为大型和多样化的数据类型提供了一种通用的基于 VR 的数据探索平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdd/8065164/54f4c8403cdd/41467_2021_22570_Fig1_HTML.jpg

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