Andersen L P, Rosenstock S J, Bonnevie O, Jørgensen T
Department of Clinical Microbiology, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
Am J Epidemiol. 1996 Jun 1;143(11):1157-64. doi: 10.1093/oxfordjournals.aje.a008694.
The seroprevalences of increased levels of immunoglobulin G (lgG), M (lgM), and A (lgA) antibodies to Helicobacter pylori were assessed by enzyme-linked immunosorbent assay techniques in 3,589 Danes who participated in a population study in Copenhagen County in 1982. A total of 33.9% of the study population had one or more classes of increased antibodies to H. pylori. Increased levels of lgG, lgM, and lgA antibodies to H. pylori were seen in 25.9% (95% confidence interval (Cl) 24.5-27.3), 4.5% (95% Cl 2.2-7.0), and 12.0% (95% Cl 10.9-13.1) of the participants, respectively. Women were significantly more likely than men to be seropositive for lgM antibodies (Mantel-Haenszel summary odds ratio = 1.85, 95% Cl 1.34-2.57). Seropositivity for lgM antibodies to H. pylori was found less often with increasing age. An lgG antibody response was not seen in 23.7% of cases with overall increased antibodies to H. pylori. Increased levels of lgG or lgA antibodies were more frequent in people with a history of peptic ulcer disease. Seroprevalences of increased H. pylori antibodies are high in unselected populations. Primary H. pylori infections are contracted at all ages, but infection rates decline with age. Inclusion of measurements of lgA and lgM antibody levels in future screening for H. pylori may improve the diagnostic sensitivity of serologic analyses.
1982年，在哥本哈根县参与一项人群研究的3589名丹麦人中，采用酶联免疫吸附测定技术评估了幽门螺杆菌免疫球蛋白G（IgG）、M（IgM）和A（IgA）抗体水平升高的血清阳性率。共有33.9%的研究人群有一种或多种类型的幽门螺杆菌抗体水平升高。幽门螺杆菌IgG、IgM和IgA抗体水平升高分别见于25.9%（95%置信区间（CI）24.5 - 27.3）、4.5%（95%CI 2.2 - 7.0）和12.0%（95%CI 10.9 - 13.1）的参与者。女性IgM抗体血清阳性的可能性显著高于男性（Mantel - Haenszel汇总比值比 = 1.85，95%CI 1.34 - 2.57）。幽门螺杆菌IgM抗体血清阳性率随年龄增长而降低。在幽门螺杆菌抗体总体升高的病例中，23.7%未出现IgG抗体反应。有消化性溃疡病史的人群中，IgG或IgA抗体水平升高更为常见。在未经过选择的人群中，幽门螺杆菌抗体水平升高的血清阳性率很高。原发性幽门螺杆菌感染在各年龄段均可发生，但感染率随年龄下降。在未来幽门螺杆菌筛查中纳入IgA和IgM抗体水平检测可能会提高血清学分析的诊断敏感性。
