Sugita Koji, Shima Ayaka, Takahashi Kaho, Matsuda Yasuyoshi, Miyajima Masaki, Hirokawa Marin, Kondo Hirotaka, Kimura Junpei, Ishihara Genki, Ohmori Keitaro
Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Sugita Animal Hospital, 3-55-10 Shinshiraoka, Shiraoka, Saitama 349-0212, Japan.
J Vet Med Sci. 2021 Jul 10;83(6):984-989. doi: 10.1292/jvms.21-0063. Epub 2021 Apr 26.
A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds.
一只7岁6个月大的去势雄性柴犬出现了1个月的嗜睡、厌食、呕吐和频繁水样腹泻病史。首次就诊时发现体重减轻、低白蛋白血症、贫血和白细胞增多。根据临床和组织病理学检查，该犬被诊断为无反应性肠病（NRE）。由于该犬对免疫抑制药物无反应，在使用苯丁酸氮芥治疗期间进行了粪便微生物群移植（FMT）。单次内镜下将FMT注入盲肠和结肠后，该犬的临床症状和临床病理异常得到了显著恢复，肠道菌群失调也得到了纠正。未观察到复发或不良事件。本病例报告表明，FMT可能与苯丁酸氮芥一起，对于预后比其他犬种更差的柴犬NRE可能是一种治疗选择。
