College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
School of Stomatology, Anhui Medical University, Hefei, 230032, China.
Eur J Pharmacol. 2021 Jul 5;902:174114. doi: 10.1016/j.ejphar.2021.174114. Epub 2021 Apr 23.
At present, emerging evidence shows that non-coding RNAs (ncRNAs) play crucial roles for development of multiple tumors. Amongst these ncRNAs, long non-coding RNAs (lncRNAs) play prominent roles in physiological and pathological processes. LncRNAs are RNA transcripts larger than 200 nucleotides and have been shown to serve important regulatory roles in different types of cancer via interactions with DNA, RNA and proteins. Head and neck squamous cell carcinoma (HNSCC) is one of the most malignant tumors with low survival rates in advanced stages. Recently, lncRNAs have been demonstrated to be involved in a wide range of biological processes, including proliferation, metastasis, and prognosis of HNSCC. Therefore, this review describes molecular mechanisms of up- or down-regulation of lncRNAs and expounds their functions in pathology and clinical practices in HNSCC. It also highlights their potential clinical applications as biomarkers for the diagnosis, prognosis, and treatment of HNSCC. However, studies on lncRNAs are still not comprehensive, and more investigations are needed in the future.
目前，新出现的证据表明非编码 RNA（ncRNA）在多种肿瘤的发生发展中起着关键作用。在这些 ncRNA 中，长非编码 RNA（lncRNA）在生理和病理过程中发挥着重要的调节作用。lncRNA 是长度大于 200 个核苷酸的 RNA 转录物，已被证明通过与 DNA、RNA 和蛋白质的相互作用，在不同类型的癌症中发挥重要的调节作用。头颈部鳞状细胞癌（HNSCC）是生存率较低的最恶性肿瘤之一。最近，lncRNA 已被证明参与了广泛的生物学过程，包括 HNSCC 的增殖、转移和预后。因此，本综述描述了 lncRNA 的上调或下调的分子机制，并阐述了它们在 HNSCC 病理学和临床实践中的功能。还强调了它们作为 HNSCC 诊断、预后和治疗的生物标志物的潜在临床应用。然而，lncRNA 的研究仍不全面，未来还需要更多的研究。
