阿尔茨海默病的生化测量结果表明，需要改进神经成像技术来研究新陈代谢。
Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism.
作者信息
Najlerahim A, Bowen D M
机构信息
Miriam Marks Department of Neurochemistry, University of London, U.K.
出版信息
Biochem J. 1988 Apr 1;251(1):305-8. doi: 10.1042/bj2510305.
Abstract
A series of Alzheimer's disease and control brains were dissected to determine the extent of atrophy (based on total protein content) and loss of choline acetyltransferase activity in the cerebral cortex from the entire surface of the diseased brains. The distribution of intensity of pathology so determined is strikingly similar to the degree of hypometabolism as shown by positron emission tomography. It is argued that the hypometabolism can be explained (at least in part) by focal areas of atrophy.
摘要
解剖了一系列阿尔茨海默病患者的大脑和对照大脑，以确定萎缩程度（基于总蛋白含量）以及患病大脑整个表面的大脑皮质中胆碱乙酰转移酶活性的丧失情况。如此确定的病理强度分布与正电子发射断层扫描显示的代谢减退程度惊人地相似。有人认为，代谢减退（至少部分）可以用萎缩的局部区域来解释。
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