Schachern P A, Paparella M M, Goycoolea M V, Duvall A J, Choo Y B
Arch Otolaryngol Head Neck Surg. 1987 Jun;113(6):625-9. doi: 10.1001/archotol.1987.01860060051014.
Studies of the permeability of the round window membrane (RWM) during otitis media are important because toxins and cellular components that occur in otitis media as well as pharmacologic agents used in treating the disease have the potential to cross the RWM and pass into the inner ear. Twenty-five cats were evaluated electron microscopically as to the passage of a tracer, horseradish peroxidase, through normal RWMs and RWMs three days, one week, and two weeks following eustachian tube obstruction. Passage at three days following obstruction was similar to passage through the normal RWM. Following one to two weeks of obstruction, the permeability of the membrane was drastically reduced. The reduction in permeability was probably due to the presence of residual effusion overlying the membrane, the presence of granulation tissue within the niche, and a thickening of the RWM.
研究中耳积液时圆窗膜（RWM）的通透性很重要，因为中耳积液中出现的毒素和细胞成分以及用于治疗该疾病的药物制剂都有可能穿过圆窗膜进入内耳。对25只猫进行了电子显微镜评估，以观察示踪剂辣根过氧化物酶通过正常圆窗膜以及咽鼓管阻塞后三天、一周和两周的圆窗膜的情况。阻塞后三天的通过情况与通过正常圆窗膜的情况相似。阻塞一到两周后，膜的通透性急剧降低。通透性降低可能是由于膜上残留积液的存在、龛内肉芽组织的存在以及圆窗膜的增厚。
