Aasland R, Lillehaug J R, Male R, Jøsendal O, Varhaug J E, Kleppe K
Laboratory of Biotechnology, University of Bergen, Norway.
Br J Cancer. 1988 Apr;57(4):358-63. doi: 10.1038/bjc.1988.82.
The receptor-type oncogenes c-erbB2/neu and c-erbB have been found amplified and/or overexpressed in a number of tumours of epithelial origin. We have studied the expression of oncogenes in biopsies from human thyroid tumours. The c-erbB2/neu and c-erbB oncogenes showed two- to three-fold higher levels of RNA in papillary carcinomas and lymph node metastases as well as in one adenoma when compared to non-tumour tissue. The nuclear oncogenes c-myc and c-fos were found to be expressed at varying levels in both non-tumour and tumour tissue. RNA transcripts specific for the platelet-derived growth factor A and B chains and the N-ras oncogene were detected in one anaplastic carcinoma. Neither rearrangements nor amplifications of oncogenes were observed in the thyroid tumours. These data are particularly interesting in light of the recent findings that epidermal growth factor induces proliferation and dedifferentiation of normal thyroid epithelial cells in vitro. We suggest that the epidermal growth factor or other ligands for the c-erbB and c-erbB2/neu receptors may contribute to the development and/or maintenance of the malignant phenotype of papillary carcinomas of the thyroid.
已发现受体型癌基因c-erbB2/neu和c-erbB在许多上皮来源的肿瘤中发生扩增和/或过表达。我们研究了人甲状腺肿瘤活检组织中癌基因的表达情况。与非肿瘤组织相比，c-erbB2/neu和c-erbB癌基因在乳头状癌、淋巴结转移灶以及1例腺瘤中的RNA水平高出两到三倍。核癌基因c-myc和c-fos在非肿瘤组织和肿瘤组织中均有不同程度的表达。在1例未分化癌中检测到血小板衍生生长因子A链和B链以及N-ras癌基因的特异性RNA转录本。在甲状腺肿瘤中未观察到癌基因的重排或扩增。鉴于最近有研究发现表皮生长因子在体外可诱导正常甲状腺上皮细胞增殖和去分化，这些数据尤其令人关注。我们认为表皮生长因子或c-erbB和c-erbB2/neu受体的其他配体可能参与甲状腺乳头状癌恶性表型的发生和/或维持。
