Banerjee Sayantan, Denning David W, Chakrabarti Arunaloke
Department of Infectious Diseases, Beleghata Infectious Diseases & BG Hospitals, Beleghata, Kolkata, West Bengal, India.
Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom; Global Action Fund for Fungal Infections, Geneva, Switzerland.
Indian J Med Res. 2021 Mar;153(3):311-319. doi: 10.4103/ijmr.IJMR_768_21.
Fungal diseases have not been taken seriously in public health agendas as well as research priorities, despite of globally causing an estimated two million deaths every year, and the emergence of many troublesome fungal pathogens like Candida auris, azole resistant Aspergillus fumigatus, terbinafine and azole resistant dermatophytes, and zoonotic sporotrichosis in humans. Fungi are also responsible for huge losses of agricultural products and stored crops as well as recent massive and unexpected mortality in animals caused by white-nose syndrome in the bats and Chytridiomycosis in amphibians. This review aims to underscore the need for collaborative, multisectoral, and trans-disciplinary approach to include the One Health approach as an essential component of surveillance, prevention, and control of globally emerging fungal diseases. Rigorous evidence based surveillance of the environment as well as strengthening rapid and quality diagnosis of fungal diseases can save millions of lives and reduce significant morbidity.
尽管真菌疾病在全球范围内每年估计导致200万人死亡,并且出现了许多麻烦的真菌病原体,如耳念珠菌、对唑类耐药的烟曲霉、对特比萘芬和唑类耐药的皮肤癣菌以及人兽共患的孢子丝菌病,但在公共卫生议程和研究重点中,真菌疾病并未得到重视。真菌还导致农产品和储存作物的巨大损失,以及近期蝙蝠白鼻综合征和两栖动物壶菌病在动物中造成的大规模意外死亡。本综述旨在强调需要采取协作、多部门和跨学科的方法,将“同一健康”方法作为全球新出现真菌疾病监测、预防和控制的重要组成部分。对环境进行严格的循证监测以及加强真菌疾病的快速和高质量诊断可以挽救数百万人的生命并减少严重的发病率。