Córdova Luisser Dainner Saavedra, Vega Alexander Pieter Mayor, Luján-Carpio Elmer, Parodi José Francisco, Moncada-Mapelli Enrique, Armacanqui-Valencia Isai, Salvador-Ruiz Jhonatanael, Pawer-Pucurimay Dalia, Ydrogo-Cruz Erickson, Chevarría-Arriaga Mylenka Jennifer, Ganoza-Farro Macarena, Meza-Romero Araceli, Zegarra-Rodríguez Cynthia Alejandra, Albán-Murguia Pedro Gustavo, Bailón-Valdez Zaira, Palacios-Garcia Naheilli, Quevedo-La-Torre Danae, Alcós-Mamani Angelica Lizeth, Gómez-Martel Luisa Alisson, Roca-Moscoso Max Antonio, Gamboa-Orozco Martin, Salazar-Granara Alberto
Universidad de San Martín de Porres, School of Medicine - Lima, Peru.
Research Centre of Traditional Medicine and Pharmacology, School of Medicine, Universidad de San Martín de Porres - Lima, Peru.
Dement Neuropsychol. 2021 Jan-Mar;15(1):1-15. doi: 10.1590/1980-57642021dn15-010001.
In the context of the current COVID-19 pandemic, higher morbidity and mortality have been reported in older adults. This age group presents physiological changes and its own clinical conditions such as frailty, dementia, among others.
To describe the characteristics of COVID-19 patients, both over and under 80 years old, by conducting a systematic review of the literature describing case reports, and to summarize and critically assess these characteristics.
Systematic review. The study was registered on the Registry of Health Research Projects (PRISA) of the Peruvian National Institute of Health (code EI00000631). Five electronic databases (Scopus, PubMed, PubMed Central, LILACS, and SCIELO) were systematically searched during the period between December 31, 2019 and April 16, 2020. The search focused on case reports, case studies, and case series of older people with COVID-19 infection aged over or under 80 years. When selecting the cases, priority was given to clinical and epidemiological profile, laboratory and imaging patterns, and comprehensive geriatric evaluation.
1,149 articles were identified; after applying the filters, a total of 15 publications of case reports and complete records of 27 older adults were obtained. The most frequent age group was between 60 to 69 years old. There is little literature regarding case reports of older adults aged over 80 years. The most frequent parameters were hypertension, fever, cough, respiratory distress, ground-glass opacification in chest radiography and tomography. Furthermore, decrease in PaO/FiO ratio and lymphocytes, and increase in C-reactive protein and Interleukin 6 were observed.
This systematic review found little available information of patients under 80 years old, and far less for those over 80 years old, and an absence of comprehensive geriatric assessment.
在当前新冠疫情背景下，据报道老年人的发病率和死亡率更高。这个年龄组存在生理变化以及自身的临床状况，如虚弱、痴呆等。
通过对描述病例报告的文献进行系统综述，描述80岁及以上和80岁以下新冠患者的特征，并总结和批判性评估这些特征。
系统综述。该研究已在秘鲁国家卫生研究所的卫生研究项目注册登记处（PRISA）登记（代码EI00000631）。在2019年12月31日至2020年4月16日期间，对五个电子数据库（Scopus、PubMed、PubMed Central、LILACS和SCIELO）进行了系统检索。检索重点是80岁及以上或80岁以下新冠感染老年人的病例报告、病例研究和病例系列。在选择病例时，优先考虑临床和流行病学特征、实验室和影像学模式以及综合老年评估。
共识别出1149篇文章；应用筛选条件后，共获得15篇病例报告出版物和27名老年人的完整记录。最常见的年龄组是60至69岁。关于80岁以上老年人病例报告的文献很少。最常见的参数是高血压、发热、咳嗽、呼吸窘迫、胸部X线和断层扫描中的磨玻璃影。此外，观察到动脉血氧分压/吸入氧分数比值和淋巴细胞减少，C反应蛋白和白细胞介素6升高。
这项系统综述发现，关于80岁以下患者的可用信息很少，80岁以上患者的信息更少，且缺乏综合老年评估。
