Fallenius A G, Franzén S A, Auer G U
Department of Tumor Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.
Cancer. 1988 Aug 1;62(3):521-30. doi: 10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f.
The predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors was studied in 227 consecutive cases of invasive breast adenocarcinomas with follow-up periods of 8 to 13 years. The results show that, with the use of Cox multivariate analysis nuclear DNA content provided significant prognostic information additional to that given by all other clinical and histomorphologic variables taken together. This fact indicates that the DNA content of breast cancer cells reflects biological properties, associated with the malignant behavior of the tumor, other than those determining the stage of the disease. Nuclear DNA content was strongly correlated to histopathologic grading of the ductal carcinomas, with poorly differentiated tumors more likely to be aneuploid. On the other hand, no clear correlation was found to exist between nuclear DNA content and axillary node status, indicating that these two factors are independent prognostic parameters. It is noteworthy that DNA content provided additional prognostic information within both the node-negative and node-positive patient groups. In summary, the results shown here indicate that nuclear DNA content, as an objective biological marker of tumor aggressiveness, can significantly improve our prognostic capabilities within the currently designated stages.
对227例连续的浸润性乳腺腺癌患者进行了研究，随访时间为8至13年，以探讨核DNA含量在乳腺癌中与临床及形态学因素相关的预测价值。结果显示，使用Cox多变量分析，核DNA含量除了提供所有其他临床和组织形态学变量综合提供的预后信息外，还提供了显著的预后信息。这一事实表明，乳腺癌细胞的DNA含量反映了与肿瘤恶性行为相关的生物学特性，而非决定疾病分期的那些特性。核DNA含量与导管癌的组织病理学分级密切相关，低分化肿瘤更可能为非整倍体。另一方面，未发现核DNA含量与腋窝淋巴结状态之间存在明确的相关性，表明这两个因素是独立的预后参数。值得注意的是，DNA含量在淋巴结阴性和阳性患者组中均提供了额外的预后信息。总之，此处所示结果表明，核DNA含量作为肿瘤侵袭性的客观生物学标志物，可在当前指定分期内显著提高我们的预后评估能力。
