Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
(Bio)Nanotechnology and Hepato/Renal Pathobiology Programs, Bio&Nano Solutions-LAB3BIO, Bielefeld, Germany.
J Mater Chem B. 2021 May 19;9(19):3967-3982. doi: 10.1039/d1tb00155h.
Cancers of the gastrointestinal tract constitute one of the most common cancer types worldwide and a ∼58% increase in the global number of cases has been estimated by IARC for the next twenty years. Recent advances in drug delivery technologies have attracted scientific interest for developing and utilizing efficient therapeutic systems. The present review focuses on the use of nanoscale MOFs (Nano-MOFs) as carriers for drug delivery and imaging purposes. In pursuit of significant improvements to current gastrointestinal cancer chemotherapy regimens, systems that allow multiple concomitant therapeutic options (polytherapy) and controlled release are highly desirable. In this sense, MOF-based nanotherapeutics represent a significant step towards achieving this goal. Here, the current state-of-the-art of interdisciplinary research and novel developments into MOF-based gastrointestinal cancer therapy are highlighted and reviewed.
胃肠道癌症是全球最常见的癌症类型之一，据 IARC 估计，未来 20 年全球癌症病例数将增加约 58%。药物输送技术的最新进展引起了科学界的兴趣，促使人们开发和利用有效的治疗系统。本综述重点介绍了纳米级金属有机骨架（Nano-MOFs）作为药物输送和成像载体的应用。为了显著改善当前胃肠道癌症的化疗方案，人们非常希望开发出能够实现多种联合治疗选择（多疗法）和控制释放的系统。在这方面，基于 MOF 的纳米治疗代表了实现这一目标的重要一步。本文重点介绍了基于 MOF 的胃肠道癌症治疗的跨学科研究和新进展的现状。
