通过硅叶立德催化实现嗪的激活。

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, Mülheim an der Ruhr, 45470, Germany.

J Am Chem Soc. 2021 May 12;143(18):6817-6822. doi: 10.1021/jacs.1c03257. Epub 2021 Apr 28.

Practical, efficient, and general methods for the diversification of -heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.

实用、高效、通用的方法来多样化 -杂环化合物一直是化学合成中的一个反复出现的目标，因为这些结构在生物活性框架中无处不在。在这里，我们通过硅鎓活化描述了嗪的直接、催化和选择性官能化。我们的催化剂设计在一锅法中实现了温和的条件和显著的官能团耐受性。