Ballinger Tarah J, Althouse Sandra K, Olsen Timothy P, Miller Kathy D, Sledge Jeffrey S
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Department of Urban and Regional Planning, University of Wisconsin, Madison, WI, United States.
Front Oncol. 2021 Apr 12;11:626180. doi: 10.3389/fonc.2021.626180. eCollection 2021.
Despite survival and quality of life benefits associated with physical activity, many breast cancer survivors remain inactive. Effective, sustainable interventions must account for individual differences in capability, motivation, and environment. Here, we evaluate the feasibility, mechanics, and efficacy of delivering an individualized, dynamic intervention to increase energetic capacity and energy expenditure.
Stage 0-III breast cancer patients who had completed primary treatment were enrolled. Prior to the intervention, detailed movement data was collected with a wearable GPS and accelerometer for 3 weeks to establish baseline activity. Movement data was collected continuously throughout the 12-week intervention, during which patients received electronically delivered, tailored, dynamic activity "prescriptions", adjusted based on demonstrated individual capability, daily movement in their environment, and progress.
Of 66 enrolled, 57 participants began and completed the intervention. The intervention resulted in significant improvements in average steps (+558 steps/day, p = 0.01), energetic capacity measured by power generation on a stationary bicycle (1.76 to 1.99 W/kg lean mass, p < 0.01), and quality of life (FACT-B TOI, 72.8 to 74.8, p = 0.02). The greatest improvement in functional energetic capacity was seen in the lowest performing tertile at baseline (0.76 to 1.12 W/kg, p < 0.01).
Wearable technology delivery of personalized activity prescriptions based on individual capability and movement behaviors demonstrates feasibility and early effectiveness. The high variability seen in baseline activity and function, as well as in response to the intervention, supports the need for future work in precision approaches to physical activity (NCT03158519).
尽管体育活动对乳腺癌幸存者的生存和生活质量有益，但许多幸存者仍缺乏运动。有效的、可持续的干预措施必须考虑到个体在能力、动机和环境方面的差异。在此，我们评估提供个性化动态干预以提高能量容量和能量消耗的可行性、机制和效果。
纳入已完成初始治疗的0-III期乳腺癌患者。在干预前，使用可穿戴式GPS和加速度计收集3周的详细运动数据以建立基线活动量。在为期12周的干预过程中持续收集运动数据，在此期间患者接收通过电子方式提供的、量身定制的动态活动“处方”，并根据个体能力表现、其所处环境中的日常活动以及进展情况进行调整。
66名入组患者中，57名参与者开始并完成了干预。干预后，平均步数显著增加（+558步/天，p = 0.01），通过固定自行车发电测量的能量容量得到显著改善（从1.76瓦/千克去脂体重增至1.99瓦/千克，p < 0.01），生活质量也有所提高（FACT-B TOI从72.8提高到74.8，p = 0.02）。在基线时表现最差的三分位数组中，功能性能量容量改善最为显著（从0.76瓦/千克增至1.12瓦/千克，p < 0.01）。
基于个体能力和运动行为通过可穿戴技术提供个性化活动处方证明了其可行性和早期有效性。基线活动量和功能以及对干预的反应中存在的高度变异性，支持了未来在体育活动精准方法方面开展工作的必要性（NCT03158519）。
