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新冠病毒检测阳性率的预测能力。

Predictive Capacity of COVID-19 Test Positivity Rate.

机构信息

Italian National Institute of Statistics, 00184 Roma, Italy.

Department of Computer Science and Engineering, University of Bologna, 40126 Bologna, Italy.

出版信息

Sensors (Basel). 2021 Apr 1;21(7):2435. doi: 10.3390/s21072435.

Abstract

COVID-19 infections can spread silently, due to the simultaneous presence of significant numbers of both critical and asymptomatic to mild cases. While, for the former reliable data are available (in the form of number of hospitalization and/or beds in intensive care units), this is not the case of the latter. Hence, analytical tools designed to generate reliable forecast and future scenarios, should be implemented to help decision-makers to plan ahead (e.g., medical structures and equipment). Previous work of one of the authors shows that an alternative formulation of the Test Positivity Rate (TPR), i.e., the proportion of the number of persons tested positive in a given day, exhibits a strong correlation with the number of patients admitted in hospitals and intensive care units. In this paper, we investigate the lagged correlation structure between the newly defined TPR and the hospitalized people time series, exploiting a rigorous statistical model, the Seasonal Auto Regressive Moving Average (SARIMA). The rigorous analytical framework chosen, i.e., the stochastic processes theory, allowed for a reliable forecasting about 12 days ahead of those quantities. The proposed approach would also allow decision-makers to forecast the number of beds in hospitals and intensive care units needed 12 days ahead. The obtained results show that a standardized TPR index is a valuable metric to monitor the growth of the COVID-19 epidemic. The index can be computed on daily basis and it is probably one of the best forecasting tools available today for predicting hospital and intensive care units overload, being an optimal compromise between simplicity of calculation and accuracy.

摘要

由于同时存在大量重症和无症状到轻症病例,COVID-19 感染可能会悄无声息地传播。虽然前者有可靠的数据(以住院人数和/或重症监护病房的床位数量的形式),但后者则没有。因此,应该采用旨在生成可靠预测和未来情景的分析工具,以帮助决策者提前规划(例如医疗结构和设备)。其中一位作者的先前工作表明,测试阳性率(TPR)的另一种表述形式,即给定日期内检测呈阳性的人数比例,与住院和重症监护病房的患者人数之间存在很强的相关性。在本文中,我们利用严格的统计模型——季节性自回归移动平均(SARIMA),研究了新定义的 TPR 与住院患者时间序列之间的滞后相关结构。所选的严格分析框架,即随机过程理论,可对这些数量进行大约 12 天的可靠预测。所提出的方法还可以使决策者预测未来 12 天内医院和重症监护病房所需的床位数量。所得结果表明,标准化的 TPR 指数是监测 COVID-19 疫情发展的一个有价值的指标。该指数可以按天计算,它可能是目前预测医院和重症监护病房超负荷的最佳预测工具之一,在计算简便性和准确性之间取得了最佳平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c98a/8037413/300dc52ea82c/sensors-21-02435-g001.jpg

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