Toledano-Osorio Manuel, Toledano Manuel, Manzano-Moreno Francisco Javier, Vallecillo Cristina, Vallecillo-Rivas Marta, Rodriguez-Archilla Alberto, Osorio Raquel
Colegio Máximo de Cartuja s/n, Faculty of Dentistry, University of Granada, 18071 Granada, Spain.
Medicina Clínica y Salud Pública PhD Programme, University of Granada, 18071 Granada, Spain.
Polymers (Basel). 2021 Apr 6;13(7):1172. doi: 10.3390/polym13071172.
Alveolar bone ridge resorption occurred after natural teeth loss and it can restrict the possibility of dental implants placement. The use of bone regenerative procedures is frequently required. The existing evidence regarding the efficacy of horizontal bone ridge augmentation trough guided bone regeneration (GBR) using polymeric membranes was stated. A systematic review and meta-analysis were performed. Electronic and manual literature searches were conducted. Screening process was done using the National Library of Medicine (MEDLINE by PubMed), Embase, and the Cochrane Oral Health. Included articles were randomized controlled trials and observational studies. Weighted means were calculated. Heterogeneity was determined using Higgins (2). If I2 > 50% a random-effects model was applied. It was found that the mean of horizontal bone gain was 3.95 mm, ranging from 3.19 to 4.70 mm (confidence interval 95%). Heterogeneity is I2 = 99% (confidence interval 95%) and significance of the random-effects model was < 0.001. The complications rate was 8.4% and membrane exposure was the most frequent. Through this study, we were able to conclude that the existing scientific evidence suggests that GBR using polymeric membranes is a predictable technique for achieving horizontal bone augmentation, thus, permitting a proper further implant placement.
天然牙缺失后会发生牙槽嵴吸收，这会限制种植牙植入的可能性。因此常常需要采用骨再生手术。本文阐述了关于使用聚合物膜通过引导骨再生（GBR）进行水平骨嵴增高术疗效的现有证据。我们进行了一项系统评价和荟萃分析。通过电子检索和手工检索文献。检索过程使用了美国国立医学图书馆（PubMed的MEDLINE）、Embase和Cochrane口腔健康数据库。纳入的文章为随机对照试验和观察性研究。计算加权均值。使用希金斯（2）方法确定异质性。如果I2>50%，则应用随机效应模型。结果发现，水平骨增量的均值为3.95毫米，范围在3.19至4.70毫米之间（95%置信区间）。异质性I2 = 99%（95%置信区间），随机效应模型的显著性<0.001。并发症发生率为8.4%，其中膜暴露最为常见。通过本研究，我们能够得出结论，现有科学证据表明，使用聚合物膜的引导骨再生是一种可预测的实现水平骨增量的技术，从而允许进行合适的进一步种植体植入。
