Winkler Laura Al-Dakhiel, Gudex Claire, Lichtenstein Mia Beck, Røder Michael Ejnar, Adair Carol E, Sjögren Jan Magnus, Støving René Klinkby
Center for Eating Disorders, Research Unit for Medical Endocrinology, Odense University Hospital, Mental Health Services in the Region of Southern Denmark, DK-5000 Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark.
J Clin Med. 2021 Apr 9;10(8):1592. doi: 10.3390/jcm10081592.
A better understanding of explanatory factors for disease-specific health-related quality of life (HRQoL) in anorexia nervosa (AN) could help direct treatment providers to aspects of the most relevance for patient wellbeing and recovery. We aimed to investigate whether factors associated with HRQoL are the same for women with AN and normal-weight controls. The participants in this study were women with AN recruited from specialized eating disorder centers in Denmark and healthy, normal-weight controls invited via online social media. Participants completed online questionnaires on medical history, disease-specific HRQoL (Eating Disorders Quality of Life Scale, EDQLS) and generic HRQoL (SF-36), eating disorder symptomatology, depression, psychological wellbeing, and work and social adjustment. Questionnaires were fully completed by 211 women with AN (median age 21.7 years) and 199 controls (median age 23.9 years). Women with AN had poorer scores on all measures, i.e., worse HRQoL, psychological health, and work/social functioning. Eating disorder symptomatology affected EDQLS score in both groups, but poorer HRQoL in women with AN was also significantly associated with worse scores on bulimia, maturity fears, depression, vitality, and with older age. The factors investigated together explained 79% of the variance in EDQLS score. Management of disordered self-assessment and thought processes may be of particular importance to women with AN. Greater emphasis on these aspects alongside weight gain could enhance patient-clinician alliance and contribute to better treatment outcomes.
更好地理解神经性厌食症（AN）中特定疾病的健康相关生活质量（HRQoL）的解释因素，有助于指导治疗提供者关注对患者幸福感和康复最为相关的方面。我们旨在调查与AN女性患者和正常体重对照组相比，与HRQoL相关的因素是否相同。本研究的参与者是从丹麦专门的饮食失调中心招募的AN女性患者，以及通过在线社交媒体邀请的健康、正常体重的对照组。参与者完成了关于病史、特定疾病的HRQoL（饮食失调生活质量量表，EDQLS）和一般HRQoL（SF-36）、饮食失调症状、抑郁、心理健康以及工作和社会适应的在线问卷。211名AN女性患者（中位年龄21.7岁）和199名对照组（中位年龄23.9岁）完全完成了问卷。AN女性患者在所有测量指标上得分更低，即HRQoL、心理健康以及工作/社会功能更差。饮食失调症状在两组中均影响EDQLS得分，但AN女性患者较差的HRQoL也与贪食、成熟恐惧、抑郁、活力得分更差以及年龄较大显著相关。共同研究的因素解释了EDQLS得分中79%的方差。对自我评估和思维过程紊乱的管理对AN女性患者可能尤为重要。在增加体重的同时，更多地强调这些方面可以加强医患联盟，并有助于取得更好的治疗效果。
