Palrasu Manikandan, Zaika Elena, El-Rifai Wael, Que Jianwen, Zaika Alexander I
Department of Surgery, University of Miami, Miami, FL 33136, USA.
Department of Veterans Affairs, Miami VA Healthcare System, Miami, FL 33136, USA.
Cancers (Basel). 2021 Apr 14;13(8):1878. doi: 10.3390/cancers13081878.
Gastric cancer (GC) is one of the deadliest malignancies worldwide. In contrast to many other tumor types, gastric carcinogenesis is tightly linked to infectious events. Infections with () bacterium and Epstein-Barr virus (EBV) are the two most investigated risk factors for GC. These pathogens infect more than half of the world's population. Fortunately, only a small fraction of infected individuals develops GC, suggesting high complexity of tumorigenic processes in the human stomach. Recent studies suggest that the multifaceted interplay between microbial, environmental, and host genetic factors underlies gastric tumorigenesis. Many aspects of these interactions still remain unclear. In this review, we update on recent discoveries, focusing on the roles of various gastric pathogens and gastric microbiome in tumorigenesis.
胃癌（GC）是全球最致命的恶性肿瘤之一。与许多其他肿瘤类型不同，胃癌的发生与感染事件密切相关。幽门螺杆菌（）感染和爱泼斯坦-巴尔病毒（EBV）感染是针对胃癌研究最多的两个风险因素。这些病原体感染了全球一半以上的人口。幸运的是，只有一小部分感染者会患上胃癌，这表明人类胃部肿瘤发生过程具有高度复杂性。最近的研究表明，微生物、环境和宿主遗传因素之间的多方面相互作用是胃癌发生的基础。这些相互作用的许多方面仍不清楚。在本综述中，我们更新了最近的发现，重点关注各种胃部病原体和胃部微生物群在肿瘤发生中的作用。
